Abstract
Background: Patients with chronic obstructive pulmonary disease (COPD) or metabolic syndrome (MS) present systemic inflammation and the association between diseases can increase risk of cardiovascular events. However, the influence of MS in survival of COPD patients is still unclear. Methods: We followed 115 COPD patients (age:64.5 ± 1.21years, FEV1:58.7 ± 2.75%) during five years and causes of death were noted. At baseline, patients' clinical history and physical examination were assessed, and anthropometric (weight, height, body mass index and waist circumference), spirometry, 6-minute walking distance (6MWD), dyspnea perception by the modified medical research council (MMRC), serum lipid profile and triglycerides measurements were performed. The diagnosis of MS was established by harmonization MS criteria. The Cox proportional hazard analysis was used to evaluate the influence of MS in the survival time, adjusted for potential confounders (age, gender and BODE index). Results: MS was present in 35.6% of patients and hypertension (47.8%) was the MS component more prevalent. More than 80% of the patients presented at least one diagnostic component of MS. During the period of study, 17.0% died. We did not observe statistical difference in mortality between groups with and without MS (HR:1.30, 95%CI: 0.32-5.20). Conclusion: Patients with COPD have intermediate prevalence of MS; however, no association between MS and mortality was found in these patients.
- © 2012 ERS
