Skip to main content

Main menu

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • COVID-19 submission information
    • Peer reviewer login
  • Alerts
  • Podcasts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • COVID-19 submission information
    • Peer reviewer login
  • Alerts
  • Podcasts
  • Subscriptions

Exercise training in pulmonary arterial hypertension associated with connective tissue diseases

Ekkehard Gruenig, Felicitas Maier, Nicola Ehlken, Christine Fischer, Mona Lichtblau, Norbert Blank, Christoph Fiehn, Frank Stöckl, Felix Prange, Gerd Staehler, Frank Reichenberger, Henning Thide, Michael Halank, Hans-Jürgen Seyfrath, Simone Wagner, Christian Nagel
European Respiratory Journal 2012 40: P4433; DOI:
Ekkehard Gruenig
1Center of Pulmonary Hypertension, Thoraxclinic Heidelberg, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Felicitas Maier
1Center of Pulmonary Hypertension, Thoraxclinic Heidelberg, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nicola Ehlken
1Center of Pulmonary Hypertension, Thoraxclinic Heidelberg, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Christine Fischer
2Departments of Human Genetics, University of Heidelberg, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mona Lichtblau
1Center of Pulmonary Hypertension, Thoraxclinic Heidelberg, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Norbert Blank
3Rheumatology and Neurology, University of Heidelberg, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Christoph Fiehn
4Rheumatology, ACURA Centre for Rheumatic Diseases, Baden-Baden, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Frank Stöckl
5Medical Clinic III, Clinic of Darmstadt, Darmstadt, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Felix Prange
1Center of Pulmonary Hypertension, Thoraxclinic Heidelberg, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gerd Staehler
6Medical Clinic I, Clinic of Loewenstein, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Frank Reichenberger
7Departments of Pneumology, Universities of Giessen, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Henning Thide
7Departments of Pneumology, Universities of Giessen, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Michael Halank
8Departments of Pneumology, Medical Clinic, Dresden, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hans-Jürgen Seyfrath
9Departments of Pneumology, University of Leipzig, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Simone Wagner
3Rheumatology and Neurology, University of Heidelberg, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Christian Nagel
1Center of Pulmonary Hypertension, Thoraxclinic Heidelberg, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Abstract

Background: The objective of this prospective study was to assess short-and long-term efficacy of exercise training(ET) as add-on to medical therapy in patients with connective tissue diseases-associated pulmonary arterial hypertension(CTD-APAH).

Patients with invasively confirmed CTD-APAH received ET in-hospital for 3 weeks and continued at home for 15 weeks. Efficacy parameters have been evaluated at baseline and after 15 weeks by blinded-observers. Survival rate has been evaluated in a follow-up period of 2.9±1.9 years.

Results: Twenty-one consecutive patients were included and assessed at baseline, and after 3 weeks, 12 after 15 weeks. Patients significantly improved the mean distance walked in 6 minutes compared to baseline by 67±52 meters after 3 weeks(p<0.001) and by 71±35 meters after 15 weeks(p=0.003), scores of quality of life(p<0.05), heart rate at rest and maximal workload. Systolic pulmonary artery pressure and diastolic systemic blood pressure improved significantly after 3 weeks of ET. The 1- and 2-year overall-survival rates were 100%, the 3-year survival 73%. In one patient lung transplantation was performed 6 months after ET.

Conclusion: ET as add-on to medical therapy is effective in patients with CTD-APAH to improve work capacity, quality of life and prognostic parameters and improves the 1-, 2- and 3-year survival rate. Further randomized controlled studies are needed to confirm these results.

Figure
  • Download figure
  • Open in new tab
  • Download powerpoint

  • Pulmonary hypertension
  • Exercise
  • Treatments
  • © 2012 ERS
Previous
Back to top
Vol 40 Issue Suppl 56 Table of Contents
  • Table of Contents
  • Index by author
Email

Thank you for your interest in spreading the word on European Respiratory Society .

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Exercise training in pulmonary arterial hypertension associated with connective tissue diseases
(Your Name) has sent you a message from European Respiratory Society
(Your Name) thought you would like to see the European Respiratory Society web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Exercise training in pulmonary arterial hypertension associated with connective tissue diseases
Ekkehard Gruenig, Felicitas Maier, Nicola Ehlken, Christine Fischer, Mona Lichtblau, Norbert Blank, Christoph Fiehn, Frank Stöckl, Felix Prange, Gerd Staehler, Frank Reichenberger, Henning Thide, Michael Halank, Hans-Jürgen Seyfrath, Simone Wagner, Christian Nagel
European Respiratory Journal Sep 2012, 40 (Suppl 56) P4433;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Exercise training in pulmonary arterial hypertension associated with connective tissue diseases
Ekkehard Gruenig, Felicitas Maier, Nicola Ehlken, Christine Fischer, Mona Lichtblau, Norbert Blank, Christoph Fiehn, Frank Stöckl, Felix Prange, Gerd Staehler, Frank Reichenberger, Henning Thide, Michael Halank, Hans-Jürgen Seyfrath, Simone Wagner, Christian Nagel
European Respiratory Journal Sep 2012, 40 (Suppl 56) P4433;
del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo
Full Text (PDF)

Jump To

  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
  • Tweet Widget
  • Facebook Like
  • Google Plus One

More in this TOC Section

  • Respiratory muscle training (REMT) with normocapnic hyperpnoea (NH) improves respiratory muscle strength, exercise performance and ventilatory pattern in COPD patients
  • Portioning out the contribution of dead space ventilation and low CO2 set point to ventilatory inefficiency during exercise in chronic thromboembolic pulmonary hypertension
Show more 4.1 Clinical physiology and Exercise

Related Articles

Navigate

  • Home
  • Current issue
  • Archive

About the ERJ

  • Journal information
  • Editorial board
  • Reviewers
  • Press
  • Permissions and reprints
  • Advertising

The European Respiratory Society

  • Society home
  • myERS
  • Privacy policy
  • Accessibility

ERS publications

  • European Respiratory Journal
  • ERJ Open Research
  • European Respiratory Review
  • Breathe
  • ERS books online
  • ERS Bookshop

Help

  • Feedback

For authors

  • Instructions for authors
  • Publication ethics and malpractice
  • Submit a manuscript

For readers

  • Alerts
  • Subjects
  • Podcasts
  • RSS

Subscriptions

  • Accessing the ERS publications

Contact us

European Respiratory Society
442 Glossop Road
Sheffield S10 2PX
United Kingdom
Tel: +44 114 2672860
Email: journals@ersnet.org

ISSN

Print ISSN:  0903-1936
Online ISSN: 1399-3003

Copyright © 2023 by the European Respiratory Society