Abstract
Background: The Multiple Breath inert gas Washout (MBW) method is increasingly used in research studies to assess ventilation distribution inhomogeneity. Normative data are needed when using the method clinically.
Methods: Spirometry and triplets of nitrogen (N2) MBW using a new device (Exhalyzer D, EcoMedics AG, Duernten, Switzerland) were recorded in 284 healthy subjects aged 7-70 yrs. Mean and SD were calculated in four age groups for LCI (Lung Clearance Index), indices of peripheral airway function based on concentration normalized slope III analysis (Scond, Sacin, Pacin), concentration normalized end-tidal N2 after 6 lung volume turnovers (Cn TO6), washout time (WoT) and moment ratios (m1/m0; m2/m0).
Results are tabulated.
Conclusion: Reference values for several different indices of ventilation distribution inhomogeneity obtained in a large healthy population over a wide age range are now available allowing for clinical use of this new N2 MBW method.
- © 2012 ERS