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Ivabradine prevents salbutamol-induced disturbance of cardiac autonomic regulation in patients with chronic obstructive pulmonary disease and coronary heart disease

Rustem Zulkarneev, Naufal Zagidullin, Shamil Zagidullin, Usman Farhutdinov, Guzel Abdrahmanova
European Respiratory Journal 2012 40: P3462; DOI:
Rustem Zulkarneev
1Internal Diseases (Propedeutics) Dept., Bashkortostan State Medical University, Ufa, Bashkortostan, Russian Federation
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Naufal Zagidullin
1Internal Diseases (Propedeutics) Dept., Bashkortostan State Medical University, Ufa, Bashkortostan, Russian Federation
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Shamil Zagidullin
1Internal Diseases (Propedeutics) Dept., Bashkortostan State Medical University, Ufa, Bashkortostan, Russian Federation
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Usman Farhutdinov
1Internal Diseases (Propedeutics) Dept., Bashkortostan State Medical University, Ufa, Bashkortostan, Russian Federation
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Guzel Abdrahmanova
2Cardiology Dept., Clinical Hospital N21, Ufa, Bashkortostan, Russian Federation
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Abstract

Aim: to evaluate protective effect of If blocker ivabradine on cardiac autonomic regulation after inhalation of salbutamol in patients with COPD and coronary heart disease(CHD).

Materials and methods: 23 patients with COPD stage II-IV and CHD NYHA class I-III were included in cross-over, randomized study.Spirometry test with 400 mg salbutamol inhalation was performed at two consecutive days. Patients in group I were prescribed 5 mg ivabradine per os 3 hours before salbutamol inhalation on the 1-st study day, patients of group II received 5 mg ivabradine on the 2-nd day. Cardiac autonomic regulation was assessed via heart rate variability (HRV).

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HRV at baseline (b) and in folow-up(f) after salbutamol(S) inhalation alone and in combination with ivabradine(I)in patients with COPD and CHD

Results: salbutamol decreased the standard deviation of interbeat intervals SDNN and low-frequency LF power. If salbutamol inhalation was made after ivabradine ingestion then heart rate (HR) and LF/HF ratio decreased, normalized respiratory modulation power HF increased. Salbutamol increased FEV1 by 6.0%, p <0.01. Salbutamol with ivabradine increased FEV1 by 7.7%, p<0.01, p=0.5 vs. no ivabradine.

Conclusion:ivabradine 5 mg per os prevents alteration of cardiac autonomic regulation after inhalation of 400 mcg salbutamol in patients with COPD and CHD comorbidity.

  • COPD - management
  • Comorbidities
  • Bronchodilators
  • © 2012 ERS
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Ivabradine prevents salbutamol-induced disturbance of cardiac autonomic regulation in patients with chronic obstructive pulmonary disease and coronary heart disease
Rustem Zulkarneev, Naufal Zagidullin, Shamil Zagidullin, Usman Farhutdinov, Guzel Abdrahmanova
European Respiratory Journal Sep 2012, 40 (Suppl 56) P3462;

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Ivabradine prevents salbutamol-induced disturbance of cardiac autonomic regulation in patients with chronic obstructive pulmonary disease and coronary heart disease
Rustem Zulkarneev, Naufal Zagidullin, Shamil Zagidullin, Usman Farhutdinov, Guzel Abdrahmanova
European Respiratory Journal Sep 2012, 40 (Suppl 56) P3462;
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