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Inflammatory processes and effects of continuous positive airway pressure (CPAP) in overlap syndrome

Serkan Nural, Ersin Gunay, Bilal Halici, Mehmet Unlu
European Respiratory Journal 2012 40: P3190; DOI:
Serkan Nural
1Department of Chest Diseases, Afyon Kocatepe University, School of Medicine, Afyonkarahisar, Turkey
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Ersin Gunay
1Department of Chest Diseases, Afyon Kocatepe University, School of Medicine, Afyonkarahisar, Turkey
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Bilal Halici
1Department of Chest Diseases, Afyon Kocatepe University, School of Medicine, Afyonkarahisar, Turkey
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Mehmet Unlu
1Department of Chest Diseases, Afyon Kocatepe University, School of Medicine, Afyonkarahisar, Turkey
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Abstract

Aim: We aimed to compare serum levels of the inflammatory mediators of C-Reactive Protein (CRP), Tumor Necrosis Factor-α (TNF-α) and Asymmetric-Dimethyl-Arginine (ADMA) in Chronic Obstructive Pulmonary Disease (COPD), Obstructive Sleep Apnea Syndrome (OSAS) and their coexistence called Overlap Syndrome (OVS). Also, we planned to investigate the changes of these mediators with the treatment of continuous positive airway pressure (CPAP) in OSAS and OVS patients.

Methods: CRP, TNF-α, ADMA levels were analyzed by ELISA method with the blood samples taken from patients with COPD (N=25), OVS (N=25) and moderate-severe stage OSAS (N=25) in the morning after polysomnography application and second blood samples taken from OSAS and OVS patients who underwent regular CPAP treatment throughout 3-6 weeks.

Results: In comparison of three groups prior to CPAP treatment, ADMA levels in OSAS group were significantly lower than in COPD group (p=0.009), but CRP (p=0.478) and TNF-α (p=0.137) were similar among groups. On the basis of before-after CPAP treatment comparison, CRP levels in both OSAS and OVS groups decreased significantly (p=0.02, p=0.04), whereas TNF-α (p=0.980, p=0.144) and ADMA (p=0.321, p=0.282) levels did not display any statistical significant differences.

Conclusion: In OVS group, no significant difference was established in inflammatory mediators when compared to COPD and OSAS groups. After effective CPAP treatment, decrease in serum-CRP level in OVS and OSAS groups showed that CPAP is an effective treatment method for systemic inflammation. Nevertheless, further investigations examining the differences in ADMA, CRP and TNF-α level in patients with COPD, OSAS and OVS are required.

  • COPD - mechanism
  • Sleep disorders
  • Inflammation
  • © 2012 ERS
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Inflammatory processes and effects of continuous positive airway pressure (CPAP) in overlap syndrome
Serkan Nural, Ersin Gunay, Bilal Halici, Mehmet Unlu
European Respiratory Journal Sep 2012, 40 (Suppl 56) P3190;

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Inflammatory processes and effects of continuous positive airway pressure (CPAP) in overlap syndrome
Serkan Nural, Ersin Gunay, Bilal Halici, Mehmet Unlu
European Respiratory Journal Sep 2012, 40 (Suppl 56) P3190;
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More in this TOC Section

  • Does CPAP therapy affect sleep time in patients with obstructive sleep apnea? A prospective study
  • Comparison of peri-pharyngeal muscle recruitment during upper airway obstruction in patients with OSA and healthy subjects during wakefulness and sleep
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Show more 4.2 Sleep and Control of Breathing

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