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Endobronchial ultrasound-guided transbronchial needle aspiration in the diagnosis of intrathoracic lymph node metastases from extrathoracic malignacy

Estefania Sanchez, Felipe Andreo, Jose Sanz, Juan Ruiz
European Respiratory Journal 2012 40: P291; DOI:
Estefania Sanchez
1Respiratory Department, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain
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Felipe Andreo
2Respiratory Department, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain
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Jose Sanz
3Respiratory Department, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain
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Juan Ruiz
4Respiratory Department, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain
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Abstract

AIM:The aim of our study was to evaluate the contribution of EBUS-TBNA for diagnosing mediastinal metastases in patients with extrathoracic malignancy that underwent EBUS-TBNA for intrathoracic lymphadenopathy.

PATIENTS & METHODS:We retrospectively reviewed all patients with a concurrent or a previous diagnosis of extrathoracic malignancy who where referred for EBUS-TBNA for clinical suspicion for mediastinal and/or hilar nodal metastases.In cases where EBUS-TBNA findings were positive for malignancy they were assumed to be true-positives and no tissue confirmation was requested.Patients to whom results were not malignant and no other benign alternative diagnoses was established underwent surgical confirmation or follow-up.

RESULTS: of 117 patients,51(43.5%)cases EBUS-TBNA revealed metastatic extrathoracic malignancy,27(23%)cases a primary thoracic malignancy and in 4(3.4%)patients a benign diagnosis.In 35 were found normal lymph node,14(11.9%)underwent surgery.Other 21(17.9%)patients who had normal lymph node underwent clinical and radiological follow-up:13(11.1%)confirmed stable or regressive lymphadenopathy and 8(6.8%)patients developed radiological progression and were assumed to be false negative. The sensitivity and negative predictive value(NPV)for diagnosing thoracic nodal metastases from extrathoracic malignancy was 86.4% and 77.1% respectively.The overall accuracy was 86.3%.

CONCLUSION: EBUS-TBNA is an accurate method for the diagnosis of thoracic nodal metastases from extrathoracic malignancy with a sensibility of 86.4%,a NPV of 77.1% and an overall accuracy of 86.3%.

  • Bronchoscopy
  • Lung cancer / Oncology
  • Neoplastic diseases
  • © 2012 ERS
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Endobronchial ultrasound-guided transbronchial needle aspiration in the diagnosis of intrathoracic lymph node metastases from extrathoracic malignacy
Estefania Sanchez, Felipe Andreo, Jose Sanz, Juan Ruiz
European Respiratory Journal Sep 2012, 40 (Suppl 56) P291;

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Endobronchial ultrasound-guided transbronchial needle aspiration in the diagnosis of intrathoracic lymph node metastases from extrathoracic malignacy
Estefania Sanchez, Felipe Andreo, Jose Sanz, Juan Ruiz
European Respiratory Journal Sep 2012, 40 (Suppl 56) P291;
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