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Inhaled colistin in elderly patients with bronchiectasis and chronic bronchial infection with pseudomonas

Eva Tabernero, Ramon Alkiza, Pilar Gil, Javier Garros, David Cantero, Juan L. Artola, Luciano Ramos
European Respiratory Journal 2012 40: P2464; DOI:
Eva Tabernero
1Pneumology, Hospital Santa Marina, Bilbao, Spain
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Ramon Alkiza
1Pneumology, Hospital Santa Marina, Bilbao, Spain
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Pilar Gil
1Pneumology, Hospital Santa Marina, Bilbao, Spain
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Javier Garros
1Pneumology, Hospital Santa Marina, Bilbao, Spain
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David Cantero
1Pneumology, Hospital Santa Marina, Bilbao, Spain
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Juan L. Artola
2Dermatology, Hospital Galdakao, Galdakao, Spain
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Luciano Ramos
1Pneumology, Hospital Santa Marina, Bilbao, Spain
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Abstract

Bronchiectasis is the end result of several different illnesses and a frequent cause of admission in hospitals for elderly people and chronic diseases. Although many guidelines recommend treatment with inhaled antibiotics in non cystic fibrosis (CF) bronchiectasis in chronic bronchial infection with pseudomonas aeruginosa, there is limited evidence for elderly patients

Aims: To assess the effectiveness of inhaled colistin in elderly patients with non CF bronchiectasis and chronic bronchial pseudomonas infection

Methods: Prospective, controlled, randomized and open. We included patients with HRCT diagnosed bronchiectasis, after an acute exacerbation admission and appropriate antimicrobial therapy. We collected data on demographics, clinical and functional characteristics, admissions and sputum microbiology. We followed the patients for one year, evaluating microbiological results, functional tests, readmissions and exitus.

Results: We included 25 patients, 13 treated with inhaled colistin and 12 in control group. Four patients stopped the treatment because of adverse effects. Main results are shown in table 1

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Conclusions: Significant more patients in the treatment group achieved Pseudomonas eradication, but we could not demonstrate clinical or functional benefits in our elderly patients. These results may be due to small sample size.

Side effects were frequent.

  • Bronchiectasis
  • Elderly
  • Treatments
  • © 2012 ERS
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Inhaled colistin in elderly patients with bronchiectasis and chronic bronchial infection with pseudomonas
Eva Tabernero, Ramon Alkiza, Pilar Gil, Javier Garros, David Cantero, Juan L. Artola, Luciano Ramos
European Respiratory Journal Sep 2012, 40 (Suppl 56) P2464;

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Inhaled colistin in elderly patients with bronchiectasis and chronic bronchial infection with pseudomonas
Eva Tabernero, Ramon Alkiza, Pilar Gil, Javier Garros, David Cantero, Juan L. Artola, Luciano Ramos
European Respiratory Journal Sep 2012, 40 (Suppl 56) P2464;
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