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Subcutaneuous injection of monoclonal antibody anti-DEC205 conjugated with ovalbumin atenuates allergic lung inflammation of animals previously sensitized to allergen

Ana Paula Ligeiro de Oliveira, Eline Rampazo, Eliane Gomes, Marcio Yamamoto, Silvia Boscardin, Momtchilo Russo
European Respiratory Journal 2012 40: P2331; DOI:
Ana Paula Ligeiro de Oliveira
1Biophotonics, University Nove de Julho - UNINOVE, São Paulo, SP, Brazil
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Eline Rampazo
2Parasitology, University of São Paulo - USP, São Paulo, SP, Brazil
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Eliane Gomes
3Immunology, University of São Paulo - USP, São Paulo, SP, Brazil
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Marcio Yamamoto
2Parasitology, University of São Paulo - USP, São Paulo, SP, Brazil
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Silvia Boscardin
2Parasitology, University of São Paulo - USP, São Paulo, SP, Brazil
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Momtchilo Russo
3Immunology, University of São Paulo - USP, São Paulo, SP, Brazil
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Abstract

DEC205 (Dendritic Endothelial Cell 205) is an endocytic receptor abundant on DCs in lymphoid tissues. Ovalbumin (OVA) protein can be chemically coupled to monoclonal a-DEC-205 antibody. Here, we sought to study the effect of a-DEC205 monoclonal antibody conjugated to OVA after OVA sensitization in a model of allergic lung disease. BALB/c mice were sensitized twice with OVA/Alum on days 0 and 7 and challenged twice with intranasal OVA on days 14 and 21 (OVA/alum group). The animals received a-DEC-205-OVA treatment after OVA sensitization (OVA/DEC group). The treatment consisted of two injections of a-DEC205 a week apart. We found that treatment with a-DEC205 decreased significantly allergic inflammation as revealed by total cell numbers and eosinophils counts in bronchoalveolar lavage (BAL) fluid.

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In the group treated with a-DEC 205, but not with the isotype control, we observed a reduction of total and OVA-specific IgE antibodies as well as IL-4 and IL-5 levels in BAL. Furthermore, treatment with a-DEC 205 decreased the methacholine-induced respiratory pattern associated with allergy.Our results indicate that treatment with anti-DEC205 monoclonal antibody conjugated to OVA is effective in reducing allergic responses in animals previously sensitized to OVA. These results suggest a potential therapeutic use of a-DEC 205 in allergic disorders.

  • Asthma - mechanism
  • Immunology
  • Chronic disease
  • © 2012 ERS
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Subcutaneuous injection of monoclonal antibody anti-DEC205 conjugated with ovalbumin atenuates allergic lung inflammation of animals previously sensitized to allergen
Ana Paula Ligeiro de Oliveira, Eline Rampazo, Eliane Gomes, Marcio Yamamoto, Silvia Boscardin, Momtchilo Russo
European Respiratory Journal Sep 2012, 40 (Suppl 56) P2331;

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Subcutaneuous injection of monoclonal antibody anti-DEC205 conjugated with ovalbumin atenuates allergic lung inflammation of animals previously sensitized to allergen
Ana Paula Ligeiro de Oliveira, Eline Rampazo, Eliane Gomes, Marcio Yamamoto, Silvia Boscardin, Momtchilo Russo
European Respiratory Journal Sep 2012, 40 (Suppl 56) P2331;
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