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Peripheral Thelper1/Thelper2/Thelper17/regulatory T cell imbalance in asthmatic pregnancy

Lilla Tamási, Gergely Toldi, Attila Molvarec, Balázs Stenczer, Veronika Muller, István Ivancsó, Noémi Eszes, András Bikov, Anikó Bohács, János Rigó Jr., György Losonczy
European Respiratory Journal 2012 40: P2301; DOI:
Lilla Tamási
1Department of Pulmonology, Semmelweis University, Budapest, Hungary
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Gergely Toldi
2Semmelweis University, 1st Department of Pediatrics, Budapest, Hungary
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Attila Molvarec
3Semmelweis University, 1st Department of Obstetrics and Gynecology, Budapest, Hungary
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Balázs Stenczer
3Semmelweis University, 1st Department of Obstetrics and Gynecology, Budapest, Hungary
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Veronika Muller
1Department of Pulmonology, Semmelweis University, Budapest, Hungary
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István Ivancsó
3Semmelweis University, 1st Department of Obstetrics and Gynecology, Budapest, Hungary
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Noémi Eszes
1Department of Pulmonology, Semmelweis University, Budapest, Hungary
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András Bikov
1Department of Pulmonology, Semmelweis University, Budapest, Hungary
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Anikó Bohács
1Department of Pulmonology, Semmelweis University, Budapest, Hungary
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János Rigó Jr.
3Semmelweis University, 1st Department of Obstetrics and Gynecology, Budapest, Hungary
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György Losonczy
1Department of Pulmonology, Semmelweis University, Budapest, Hungary
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Abstract

Asthma and pregnancy show bilateral clinical interactions with mostly unknown immunological mechanisms. Healthy gestation is characterized by a sensitive balance of Th1/Th2/Th17/regulatory T (Treg) cells which may be altered in asthmatic pregnancy. The aim of this study was to describe the prevalence of these cell subsets in asthmatic compared with healthy pregnancy.

The prevalence of Th1, Th2, Th17 and Treg lymphocytes was identified by cell surface and intracellular marker staining in 24 healthy non-pregnant (HNP), 23 healthy pregnant (HP), 15 asthmatic non-pregnant (ANP) and 15 asthmatic pregnant (AP) women using flow cytometry.

HP and ANP were characterized by increased Th2/Th1 ratio compared to HNP, but no further increase was observed in AP. Healthy pregnancy increased Treg cell prevalence compared with HNP data (4.64% vs. 2.98%; p<0.05), and this pregnancy-induced elevation was absent in AP women (2.52% vs. HP; p<0.05). Th17 cell prevalence was similar in the HP and HNP groups (2.78% vs. 3.17%; p>0.05). Asthma increased Th17 prevalence in non-pregnant patients (3.81% vs. HNP; p<0.05), and this asthma specific increase of Th17 cell prevalence was also observed in AP patients (AP vs. HP: 3.44% vs. 2.78%; p<0.05). As a result, Th17/Treg ratio was decreased in HP, but not in AP women, compared with HNP data.

Peripheral Thelper1/Thelper2/Thelper17/regulatory T cell imbalance may play a role in the interrelationship and compromised immune tolerance characterizing asthmatic pregnancy.

  • Asthma - mechanism
  • Immunology
  • © 2012 ERS
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Peripheral Thelper1/Thelper2/Thelper17/regulatory T cell imbalance in asthmatic pregnancy
Lilla Tamási, Gergely Toldi, Attila Molvarec, Balázs Stenczer, Veronika Muller, István Ivancsó, Noémi Eszes, András Bikov, Anikó Bohács, János Rigó, György Losonczy
European Respiratory Journal Sep 2012, 40 (Suppl 56) P2301;

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Peripheral Thelper1/Thelper2/Thelper17/regulatory T cell imbalance in asthmatic pregnancy
Lilla Tamási, Gergely Toldi, Attila Molvarec, Balázs Stenczer, Veronika Muller, István Ivancsó, Noémi Eszes, András Bikov, Anikó Bohács, János Rigó, György Losonczy
European Respiratory Journal Sep 2012, 40 (Suppl 56) P2301;
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