Skip to main content

Main menu

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • ERS Guidelines
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • Peer reviewer login
    • WoS Reviewer Recognition Service
  • Alerts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • ERS Guidelines
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • Peer reviewer login
    • WoS Reviewer Recognition Service
  • Alerts
  • Subscriptions

Validity of serum surfactant protein D as a lung-specific biomarker in monitoring asthma, chronic obstructive pulmonary disease and chronic bronchitis in Lebanese patients: Preliminary results

Rania Jounblat, Mirna Waked, Zeina Akiki, Pascale Salameh, Hasnaa Bouharoun-Tayoun, Ida Tornøe, Grith Lykke Sørensen, Soulaima Chamat
European Respiratory Journal 2012 40: P2227; DOI:
Rania Jounblat
1Immunology Laboratory, Faculty of Health Sciences, Lebanese University, Beirut, Lebanon
2Histology, Cell and Molecular Biology Laboratory, Faculty of Sciences, Lebanese University, Beirut, Lebanon
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mirna Waked
3Saint George Hospital Medical Cente, Pulmonology Department, Faculty of Medicine, Balamand University, Beirut, Lebanon
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Zeina Akiki
1Immunology Laboratory, Faculty of Health Sciences, Lebanese University, Beirut, Lebanon
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Pascale Salameh
1Immunology Laboratory, Faculty of Health Sciences, Lebanese University, Beirut, Lebanon
4Clinical & Epidemiological Research Laboratory, Faculty of Pharmacy, Lebanese University, Beirut, Lebanon
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hasnaa Bouharoun-Tayoun
1Immunology Laboratory, Faculty of Health Sciences, Lebanese University, Beirut, Lebanon
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ida Tornøe
5Institute of Molecular Medicine, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Grith Lykke Sørensen
5Institute of Molecular Medicine, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Soulaima Chamat
1Immunology Laboratory, Faculty of Health Sciences, Lebanese University, Beirut, Lebanon
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • PDF
Loading

Abstract

Surfactant protein D (SP-D) is an oligomeric lung-derived lectin with important roles in innate host defence. Previous studies have suggested serum SP-D as a reliable biomarker for inflammatory lung diseases.

Our objective was to validate for the first time in the Lebanese population, SP-D as a clinical biomarker for asthma, COPD and chronic bronchitis. In addition, we studied the correlation between SP-D level and the disease severity. A case-control study is being conducted in the Lebanese population. To date, 46 cases of asthma, 24 cases of COPD, 23 cases of chronic bronchitis patients and 46 controls have been analysed. Lung function measurements were performed by spirometry, a standardized questionnaire was filled and serum levels of SP-D, CRP and plasma fibrinogen levels were measured.

The mean level of SP-D was significantly elevated in asthmatics (1394.26 ng.ml-1; p = 0.023), in COPD patients (1507.24 ng.ml-1; p = 0.013) and in chronic bronchitis patients (1477.27 ng.ml-1; p = 0.007) when compared to controls (980.1 ng.ml-1). Serum SP-D levels correlated significantly with the disease severity only in COPD (p = 0.007). Conversely, levels of CRP and fibrinogen did not correlate with disease severity.

We conclude that SP-D could be used as a biomarker for asthma, COPD and chronic bronchitis and seems to be more specific than general systemic markers of inflammation, CRP and fibrinogen. The ongoing study should provide further information on the cut off values and/or absolute values of serum Sp-D reflecting the degree of inflammation in the investigated diseases.

  • Biomarkers
  • Monitoring
  • Spirometry
  • © 2012 ERS
Previous
Back to top
Vol 40 Issue Suppl 56 Table of Contents
  • Table of Contents
  • Index by author
Email

Thank you for your interest in spreading the word on European Respiratory Society .

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Validity of serum surfactant protein D as a lung-specific biomarker in monitoring asthma, chronic obstructive pulmonary disease and chronic bronchitis in Lebanese patients: Preliminary results
(Your Name) has sent you a message from European Respiratory Society
(Your Name) thought you would like to see the European Respiratory Society web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Validity of serum surfactant protein D as a lung-specific biomarker in monitoring asthma, chronic obstructive pulmonary disease and chronic bronchitis in Lebanese patients: Preliminary results
Rania Jounblat, Mirna Waked, Zeina Akiki, Pascale Salameh, Hasnaa Bouharoun-Tayoun, Ida Tornøe, Grith Lykke Sørensen, Soulaima Chamat
European Respiratory Journal Sep 2012, 40 (Suppl 56) P2227;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Validity of serum surfactant protein D as a lung-specific biomarker in monitoring asthma, chronic obstructive pulmonary disease and chronic bronchitis in Lebanese patients: Preliminary results
Rania Jounblat, Mirna Waked, Zeina Akiki, Pascale Salameh, Hasnaa Bouharoun-Tayoun, Ida Tornøe, Grith Lykke Sørensen, Soulaima Chamat
European Respiratory Journal Sep 2012, 40 (Suppl 56) P2227;
del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo
Full Text (PDF)

Jump To

  • Article
  • Info & Metrics
  • PDF
  • Tweet Widget
  • Facebook Like
  • Google Plus One

More in this TOC Section

  • Respiratory outcomes in young adults following extremely preterm birth
  • Significance of quantitative radiological phenotypes of COPD on BODE index
  • Multi-modality correlation of disease in patients with chronic rhino-sinusitis (CRS) undergoing surgery
Show more 5.2 Monitoring Airway Disease

Related Articles

Navigate

  • Home
  • Current issue
  • Archive

About the ERJ

  • Journal information
  • Editorial board
  • Press
  • Permissions and reprints
  • Advertising

The European Respiratory Society

  • Society home
  • myERS
  • Privacy policy
  • Accessibility

ERS publications

  • European Respiratory Journal
  • ERJ Open Research
  • European Respiratory Review
  • Breathe
  • ERS books online
  • ERS Bookshop

Help

  • Feedback

For authors

  • Instructions for authors
  • Publication ethics and malpractice
  • Submit a manuscript

For readers

  • Alerts
  • Subjects
  • Podcasts
  • RSS

Subscriptions

  • Accessing the ERS publications

Contact us

European Respiratory Society
442 Glossop Road
Sheffield S10 2PX
United Kingdom
Tel: +44 114 2672860
Email: journals@ersnet.org

ISSN

Print ISSN:  0903-1936
Online ISSN: 1399-3003

Copyright © 2023 by the European Respiratory Society