Skip to main content

Main menu

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • ERS Guidelines
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • Peer reviewer login
  • Alerts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • ERS Guidelines
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • Peer reviewer login
  • Alerts
  • Subscriptions

In vitro evaluation of a new spacer for pMDI and nebulizers in mechanical ventilation

Nabile Boukhettala, Maria Cabrera, Patrice Diot, Thierry Porée, Laurent Vecellio
European Respiratory Journal 2012 40: P2012; DOI:
Nabile Boukhettala
1EA6305, Centre d'Etude des Pathologies Respiratoires, Tours, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Maria Cabrera
1EA6305, Centre d'Etude des Pathologies Respiratoires, Tours, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Patrice Diot
1EA6305, Centre d'Etude des Pathologies Respiratoires, Tours, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Thierry Porée
1EA6305, Centre d'Etude des Pathologies Respiratoires, Tours, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Laurent Vecellio
1EA6305, Centre d'Etude des Pathologies Respiratoires, Tours, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • PDF
Loading

Abstract

Rationale: The objective of this study was to evaluate the performances of a new prototype spacer (Combihaler, Protec'Som, France) to improve antibiotic and bronchodilator delivery either from nebulizer or pMDI

Methods: A Servo 300 ventilator (Siemens, France) set up in controlled volume (450ml, 15/min, 40/60) was connected to an endotracheal tube. An absolute filter was connected between the endotracheal tube and a lung model (Dual adult model, Michigan instrument, USA). A vibrating mesh nebulizer (Aeroneb Solo, Aerogen, Ireland) loaded with amikacine (reference) was tested with its T piece (Aerogen, Ireland) and Combihaler. A pMDI of sabutamol (100µg, Ventoline, GlaxoSmithKline, France) was tested with a connector (Minispacer, AirLife, USA) and Combihaler. All aerosol devices were connected at the “Y” piece on the inspiratory circuit. Drug delivery on filter was assay.

Results: The duration of nebulization was not statistical different between the T piece and the Combihaler (42±0,9min vs 43,2±0,9min, p>0,05). The mass of amikacin deposited on the filter was twice higher with the Combihaler chamber compared with the Aerogen T-adapter (305.6±9.3 mg vs 142.4±4.9 mg, p<0,001) corresponding of an increasing of a factor 2 in term of output rate with Combihaler (7.1±0.2 mg/min vs 3.4±0.2 mg/min; p<0,001). The mass of salbutamol deposited on the filter was 2.3 fold higher with Combihaler chamber in comparison with the connector (43.5±6.3 µg vs 18.8±1.9 µg, p<0,05).

Conclusions: In comparison with T piece or connector, the use of the Combihaler spacer allows increasing the amount of drug delivery by a factor 2 either from nebulizer or pMDI during mechanical ventilation.

  • Bronchodilators
  • Ventilation/NIV
  • Mechanical ventilation
  • © 2012 ERS
Previous
Back to top
Vol 40 Issue Suppl 56 Table of Contents
  • Table of Contents
  • Index by author
Email

Thank you for your interest in spreading the word on European Respiratory Society .

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
In vitro evaluation of a new spacer for pMDI and nebulizers in mechanical ventilation
(Your Name) has sent you a message from European Respiratory Society
(Your Name) thought you would like to see the European Respiratory Society web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
In vitro evaluation of a new spacer for pMDI and nebulizers in mechanical ventilation
Nabile Boukhettala, Maria Cabrera, Patrice Diot, Thierry Porée, Laurent Vecellio
European Respiratory Journal Sep 2012, 40 (Suppl 56) P2012;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
In vitro evaluation of a new spacer for pMDI and nebulizers in mechanical ventilation
Nabile Boukhettala, Maria Cabrera, Patrice Diot, Thierry Porée, Laurent Vecellio
European Respiratory Journal Sep 2012, 40 (Suppl 56) P2012;
del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo
Full Text (PDF)

Jump To

  • Article
  • Info & Metrics
  • PDF
  • Tweet Widget
  • Facebook Like
  • Google Plus One

More in this TOC Section

  • Central venous oxygen saturation as predictor of a successful spontaneous breathing trial outcome in mechanically ventilated patients
  • Non-invasive ventilation in the emergency department from 2004-2015
  • The negative effect of initial high-dose methylprednisolone and tapering regimen for acute respiratory distress syndrome: A retrospective propensity matched cohort study
Show more 2.1 Acute Critical Care

Related Articles

Navigate

  • Home
  • Current issue
  • Archive

About the ERJ

  • Journal information
  • Editorial board
  • Press
  • Permissions and reprints
  • Advertising

The European Respiratory Society

  • Society home
  • myERS
  • Privacy policy
  • Accessibility

ERS publications

  • European Respiratory Journal
  • ERJ Open Research
  • European Respiratory Review
  • Breathe
  • ERS books online
  • ERS Bookshop

Help

  • Feedback

For authors

  • Instructions for authors
  • Publication ethics and malpractice
  • Submit a manuscript

For readers

  • Alerts
  • Subjects
  • Podcasts
  • RSS

Subscriptions

  • Accessing the ERS publications

Contact us

European Respiratory Society
442 Glossop Road
Sheffield S10 2PX
United Kingdom
Tel: +44 114 2672860
Email: journals@ersnet.org

ISSN

Print ISSN:  0903-1936
Online ISSN: 1399-3003

Copyright © 2023 by the European Respiratory Society