Skip to main content

Main menu

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • ERS Guidelines
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • Peer reviewer login
  • Alerts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • ERS Guidelines
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • Peer reviewer login
  • Alerts
  • Subscriptions

Disappearance of hypoglycemic attacks after resection of solitary fibrous tumors with high expression of insulin-like growth factor II

Hiroyoshi Watanabe, Keiichi Akasaka, Ryouta Fukai, Tomoko Terasawa, Naoto Fueki, Kazunori Fukuda, Takayuki Haga, Yoshinori Kawabata, Yoshihiko Ueda, Hironori Sagara
European Respiratory Journal 2012 40: P1248; DOI:
Hiroyoshi Watanabe
1Dept. of Respiratory Medicine, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Saitama, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Keiichi Akasaka
1Dept. of Respiratory Medicine, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Saitama, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ryouta Fukai
2Department of Cardiovascular and Thoracic Surgery, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Saitama, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tomoko Terasawa
3Division of diabetology, endocrinology and Hematology, Dept of Internal Medicine, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Saitama, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Naoto Fueki
1Dept. of Respiratory Medicine, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Saitama, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kazunori Fukuda
4Koshigaya Hospital Joint Research Center, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Saitama, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Takayuki Haga
5Internal Medicine, East Saitama National Hospital, Hasuda, Saitama, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yoshinori Kawabata
1Dept. of Respiratory Medicine, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Saitama, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yoshihiko Ueda
6Dept. of Pathology, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Saitama, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hironori Sagara
1Dept. of Respiratory Medicine, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Saitama, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • PDF
Loading

Abstract

Hypoglycemia rarely accompanies solitary fibrous tumors (SFT) of the pleura, occurring in only about 4% of patients. We describe our experience with 2 patients whose hypoglycemic attacks disappeared after the resection of SFT.

Patient 1: The patient was an 81-year-old woman. Computed tomography of the chest showed a mass compressing the entire right lower lobe. SFT was diagnosed on histopathological examination of a percutaneous needle biopsy specimen. Subsequently, tumor resection was performed, and the hypoglycemia disappeared. Histopathologically, the tumor was associated with abundant proliferations of markedly hyalinized collagen fibers. The tumor contained small bundles of round cells or spindle cells with mild atypia, proliferating in an irregular, intermingled fashion. On immunohistochemical staining, the tumor cells were positive for CD34. Patient 2: The patient was a 77-year-old man with dyspnea on exertion. Preoperative computed tomography showed a well-demarcated, giant mass compressing the right middle lobe. Therefore, the mass was resected, and the hypoglycemia disappeared. Histopathological examination revealed proliferations of collagen fibers containing spindle cells with low-grade atypia, proliferating in an irregular storiform fashion with positive for CD34.

In both case, serum insulin level valued remarkably lower than 0.2μU/ml and the immunohistochemical staining of Insulin-like growth factor II (IGF- II) were positive.

Tumor resection was suggested to be an effective treatment for hypoglycemic attacks in patients with SFT. IGF- II may provide negative feedback with respect to insulin secretion.

  • Lung cancer / Oncology
  • Molecular pathology
  • Lung growth/development
  • © 2012 ERS
Previous
Back to top
Vol 40 Issue Suppl 56 Table of Contents
  • Table of Contents
  • Index by author
Email

Thank you for your interest in spreading the word on European Respiratory Society .

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Disappearance of hypoglycemic attacks after resection of solitary fibrous tumors with high expression of insulin-like growth factor II
(Your Name) has sent you a message from European Respiratory Society
(Your Name) thought you would like to see the European Respiratory Society web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Disappearance of hypoglycemic attacks after resection of solitary fibrous tumors with high expression of insulin-like growth factor II
Hiroyoshi Watanabe, Keiichi Akasaka, Ryouta Fukai, Tomoko Terasawa, Naoto Fueki, Kazunori Fukuda, Takayuki Haga, Yoshinori Kawabata, Yoshihiko Ueda, Hironori Sagara
European Respiratory Journal Sep 2012, 40 (Suppl 56) P1248;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Disappearance of hypoglycemic attacks after resection of solitary fibrous tumors with high expression of insulin-like growth factor II
Hiroyoshi Watanabe, Keiichi Akasaka, Ryouta Fukai, Tomoko Terasawa, Naoto Fueki, Kazunori Fukuda, Takayuki Haga, Yoshinori Kawabata, Yoshihiko Ueda, Hironori Sagara
European Respiratory Journal Sep 2012, 40 (Suppl 56) P1248;
del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo
Full Text (PDF)

Jump To

  • Article
  • Info & Metrics
  • PDF
  • Tweet Widget
  • Facebook Like
  • Google Plus One

More in this TOC Section

  • Lung adenocarcinoma mimicking interstitial lung disease showed good response to navelbine monotherapy
  • Should preoperative FDG uptake on PET/CT guide postoperative surveillance in surgical non-small cell lung cancer (NSCLC)
  • Pemetrexed in maintenance therapy of 164 patients with advanced non-small-cell lung cancer (NSCLC)
Show more 11.1 Lung Cancer

Related Articles

Navigate

  • Home
  • Current issue
  • Archive

About the ERJ

  • Journal information
  • Editorial board
  • Press
  • Permissions and reprints
  • Advertising

The European Respiratory Society

  • Society home
  • myERS
  • Privacy policy
  • Accessibility

ERS publications

  • European Respiratory Journal
  • ERJ Open Research
  • European Respiratory Review
  • Breathe
  • ERS books online
  • ERS Bookshop

Help

  • Feedback

For authors

  • Instructions for authors
  • Publication ethics and malpractice
  • Submit a manuscript

For readers

  • Alerts
  • Subjects
  • Podcasts
  • RSS

Subscriptions

  • Accessing the ERS publications

Contact us

European Respiratory Society
442 Glossop Road
Sheffield S10 2PX
United Kingdom
Tel: +44 114 2672860
Email: journals@ersnet.org

ISSN

Print ISSN:  0903-1936
Online ISSN: 1399-3003

Copyright © 2023 by the European Respiratory Society