Abstract
Introduction: FEV1 has been found to be inversely related to circulating leptin suggesting that reduced lung function could be related to high leptin levels.
Aims: To determine the association between pulmonary function with leptin in Thai children and adolescents between 12 to 18 years of age.
Methods: Pulmonary function, expressed as % predicted except FEV1%, and leptin were measured in 39 children and adolescents and divided into 3 FEV1 groups; normal (A), obese normal (B) FEV1 80% and restrictive (C) FEV1<80%.
Results: BMI were 20.2±1.6 kg/m2 in A (n=19), 32.2±4.4 kg/m2 in B (n=14) and 36.8±5.9 kg/m2 in C (n=6). Group B had comparable FEV1, FVC, MVV and FEV1% to A, whereas C had reduced FEV1 (73.8%), FVC (77.5%) and MVV (73.7%) but normal FEV1% (95.5%). All values except FEV1% were lower than B (FEV1 94.7%; FVC 97.5%; MVV 94.8%) and A (FEV1 89.6%, FVC 89.6%, MVV 89.7%). Group C had significantly higher leptin than A and B, respectively. Moreover, there was a significant negative correlation between FEV1 and MVV with leptin (FEV1, R2= 0.560; MVV, R2 =0.582).
Conclusions: The data suggest that high leptin levels could be responsible for a restrictive lung in obese Thai children and adolescents.
- © 2012 ERS