Skip to main content

Main menu

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • COVID-19 submission information
    • Peer reviewer login
  • Alerts
  • Podcasts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • COVID-19 submission information
    • Peer reviewer login
  • Alerts
  • Podcasts
  • Subscriptions

Associations among one-year efficacy outcomes following endoscopic thermal vapor ablation (InterVapor™) for heterogeneous emphysema

Peter Hopkins, Felix J.F. Herth, Gregory Snell, Kim Baker, Christian Witt, Mark H. Gotfried, Arschang Valipour, Manfred Wagner, Franz Stanzel, Jim J. Egan, Steven Kesten, Armin Ernst
European Respiratory Journal 2012 40: 4725; DOI:
Peter Hopkins
1Lung Transplant Unit, Prince Charles Hospital, Chermside, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Felix J.F. Herth
2Pneumology and Critical Care Medicine, Thoraxklinik Heidelberg, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gregory Snell
3Allergy Immunology & Respiratory Medicine, The Alfred Hospital, Melbourne, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kim Baker
4Pulmonary & Critical Care Medicine, University of Iowa, Iowa City, United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Christian Witt
5Pneumology, Charité-University Medicine, Berlin, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mark H. Gotfried
6PACT, Pulmonary Associates, Phoenix, United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Arschang Valipour
7Ludwig-Boltzmann-Institute for COPD and Respiratory Epidemiology, Otto-Wagner Hospital, Vienna, Austria
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Manfred Wagner
8Pneumologie, Klinikum Nürnberg, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Franz Stanzel
9Zentrum für Pneumologie, Lungenklinik Hemer, Nordrhein Westfalen, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jim J. Egan
10Advanced Lung Disease Program, Mater Misericordiae University Hospital, Dublin, Ireland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Steven Kesten
11Clinical Department, Uptake Medical Corp, Tustin, United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Armin Ernst
12Pulmonary, Critical Care and Sleep Medicine, St. Elizabeth's Medical Center, Boston, United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Abstract

Background: The understanding of interactions or associations over the long-term may assist in understanding and predicting changes over time in chronic diseases such as emphysema. The associations among various COPD efficacy endpoints are variable; however, the degree of correlation is often important in examining the consistency of the results across measures not considered redundant.

Objectives: Determine the correlations of improvements in patient-reported outcomes, exercise capacity and BODE score with lung function and lobar volume reduction (LoVR) measured by CT after 1-year post-InterVapor for heterogeneous emphysema.

Methods: Single-arm trial of InterVapor in patients with upper lobe emphysema. Patient criteria: FEV1 15% - 45% predicted, age 40-75 years, RV>150%, TLC>100%, 6 minute walk distance (6MWD)>140 m, DLCO>20%, previous pulmonary rehabilitation. Endpoints included: spirometry, body plethysmography, SGRQ, mMRC dyspnea, 6MWD and LoVR (CT). Pearson correlation coefficients were calculated for associations of changes from baseline to 12 months.

Results: 44 patients received InterVapor. Mean age: 63 years, men 50%, FEV1 0.86 (31% predicted), RV 237% predicted, DLCO 35% predicted, SGRQ 59 units, 6MWD 300 m, mMRC 2.9.

View this table:
  • View inline
  • View popup

Conclusion: Among lung function tests, FEV1 appeared to correlate the strongest with health outcomes, followed by RV and FRC at one year. The strong correlation of outcomes with LoVR are consistent with the proposed mechanism of action.

  • COPD - management
  • Bronchoscopy
  • Experimental approaches
  • © 2012 ERS
Previous
Back to top
Vol 40 Issue Suppl 56 Table of Contents
  • Table of Contents
  • Index by author
Email

Thank you for your interest in spreading the word on European Respiratory Society .

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Associations among one-year efficacy outcomes following endoscopic thermal vapor ablation (InterVapor™) for heterogeneous emphysema
(Your Name) has sent you a message from European Respiratory Society
(Your Name) thought you would like to see the European Respiratory Society web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Associations among one-year efficacy outcomes following endoscopic thermal vapor ablation (InterVapor™) for heterogeneous emphysema
Peter Hopkins, Felix J.F. Herth, Gregory Snell, Kim Baker, Christian Witt, Mark H. Gotfried, Arschang Valipour, Manfred Wagner, Franz Stanzel, Jim J. Egan, Steven Kesten, Armin Ernst
European Respiratory Journal Sep 2012, 40 (Suppl 56) 4725;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Associations among one-year efficacy outcomes following endoscopic thermal vapor ablation (InterVapor™) for heterogeneous emphysema
Peter Hopkins, Felix J.F. Herth, Gregory Snell, Kim Baker, Christian Witt, Mark H. Gotfried, Arschang Valipour, Manfred Wagner, Franz Stanzel, Jim J. Egan, Steven Kesten, Armin Ernst
European Respiratory Journal Sep 2012, 40 (Suppl 56) 4725;
del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo
Full Text (PDF)

Jump To

  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
  • Tweet Widget
  • Facebook Like
  • Google Plus One

More in this TOC Section

  • Comparison between bronchoscopy, closed (Abram's) and medical thoracoscopic pleural biopsies in undiagnosed pleural effusions
  • Contribution of PIPE Score on prognostic evaluation of idiopathic pleural effusions (IPE)
  • What factors influence the duration of pneumothorax drainage?
Show more 1.4 Interventional Pulmonology

Related Articles

Navigate

  • Home
  • Current issue
  • Archive

About the ERJ

  • Journal information
  • Editorial board
  • Reviewers
  • Press
  • Permissions and reprints
  • Advertising

The European Respiratory Society

  • Society home
  • myERS
  • Privacy policy
  • Accessibility

ERS publications

  • European Respiratory Journal
  • ERJ Open Research
  • European Respiratory Review
  • Breathe
  • ERS books online
  • ERS Bookshop

Help

  • Feedback

For authors

  • Instructions for authors
  • Publication ethics and malpractice
  • Submit a manuscript

For readers

  • Alerts
  • Subjects
  • Podcasts
  • RSS

Subscriptions

  • Accessing the ERS publications

Contact us

European Respiratory Society
442 Glossop Road
Sheffield S10 2PX
United Kingdom
Tel: +44 114 2672860
Email: journals@ersnet.org

ISSN

Print ISSN:  0903-1936
Online ISSN: 1399-3003

Copyright © 2022 by the European Respiratory Society