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Overexpression of inhibitor of DNA-binding proteins and angiogenic markers have higher impact on survival of non small cell lung cancer patients

Roberta Sales, Thayla Tuma, Milena Acencio, Ricardo Terra, Edwin Parra, Vera Capelozzi, Leila Antonangelo
European Respiratory Journal 2012 40: 4548; DOI:
Roberta Sales
2Pulomonary Division, Heart Institute - Incor - University of Sao Paulo, SP, Brazil
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Thayla Tuma
1Pathology and Research Laboratory (LIM 03), Hospital das Clinicas -University of Sao Paulo, SP, Brazil
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Milena Acencio
2Pulomonary Division, Heart Institute - Incor - University of Sao Paulo, SP, Brazil
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Ricardo Terra
2Pulomonary Division, Heart Institute - Incor - University of Sao Paulo, SP, Brazil
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Edwin Parra
1Pathology and Research Laboratory (LIM 03), Hospital das Clinicas -University of Sao Paulo, SP, Brazil
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Vera Capelozzi
1Pathology and Research Laboratory (LIM 03), Hospital das Clinicas -University of Sao Paulo, SP, Brazil
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Leila Antonangelo
1Pathology and Research Laboratory (LIM 03), Hospital das Clinicas -University of Sao Paulo, SP, Brazil
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Abstract

Background: The inhibitor of DNA binding (Id) proteins have been implicated in oncogenic transformation, progression and in tumor angiogenesis, the last one by regulation of vascular endothelial growth factor (VEGF) expression. Notwithstanding, these mechanisms have not been fully understood. The aim of this study was to evaluate the Ids 1,2,3 and VEGF expression and angiogenesis amount in non small cell lung cancer (NSCLC) and their role on patients' prognosis.

Methods: Immunohistochemistry and morphometry were used to evaluate Ids, VEGF expression and microvessel density (CD34+) in neoplastic and stromal cells from 85 patients with surgically excised NSCLC. The impact of these markers was tested on follow-up until death from recurrence lung cancer.

Results: The Kaplan-Meier survival curve analysis showed that expression of Id-1, CD34 and VEGF were associated with poor prognosis (Log Rank Test, p<0.001). A Cox model analysis controlled for histological type, lymph node stage, Ids, VEGF, CD34 and age demonstrated that only Id1, Id3 and vascular density were significantly associated with survival time. A point at the median for Id1, Id3 and vascular density divided patients into 2 groups, each one with distinctive prognosis. Those with higher expression of Id1, Id3 and vascular density had a higher risk of death when compared to those with lower Id-1, Id-3 and vascular density.

Conclusion: In resected NSCLC, Id1, Id3, VGF and vascular density were strongly associated with prognosis. Therefore, Id1 and Id3 seem to contribute on tumor progression and should be considered as prognostic markers in NSCLC.

  • Lung cancer / Oncology
  • Biomarkers
  • Neoplastic diseases
  • © 2012 ERS
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Overexpression of inhibitor of DNA-binding proteins and angiogenic markers have higher impact on survival of non small cell lung cancer patients
Roberta Sales, Thayla Tuma, Milena Acencio, Ricardo Terra, Edwin Parra, Vera Capelozzi, Leila Antonangelo
European Respiratory Journal Sep 2012, 40 (Suppl 56) 4548;

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Overexpression of inhibitor of DNA-binding proteins and angiogenic markers have higher impact on survival of non small cell lung cancer patients
Roberta Sales, Thayla Tuma, Milena Acencio, Ricardo Terra, Edwin Parra, Vera Capelozzi, Leila Antonangelo
European Respiratory Journal Sep 2012, 40 (Suppl 56) 4548;
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