Skip to main content

Main menu

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • For authors
    • Instructions for authors
    • Submit a manuscript
    • Author FAQs
    • Open access
    • COVID-19 submission information
  • Alerts
  • Podcasts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • For authors
    • Instructions for authors
    • Submit a manuscript
    • Author FAQs
    • Open access
    • COVID-19 submission information
  • Alerts
  • Podcasts
  • Subscriptions

Impact of CPAP treatment on the changes of maxi-k+ channel beta subunit-1 expression in patients affected by sleep apnea-hypopnea syndrome (SAHS)

Candela Caballero, Ángeles Sanchez Armengol, Mª. Jesús Dominguez-Simeón, María Abad, Carmen Carmona, Pablo Stiefel, Francisco Capote
European Respiratory Journal 2012 40: 3292; DOI:
Candela Caballero
1Unidad Médico-Quirúrgica Enfermedades Respiratorias, Virgen del Rocío Hospital, Sevilla, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ángeles Sanchez Armengol
1Unidad Médico-Quirúrgica Enfermedades Respiratorias, Virgen del Rocío Hospital, Sevilla, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mª. Jesús Dominguez-Simeón
2Unidad de Hipertensión, Virgen del Rocío Hospital, Sevilla, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
María Abad
1Unidad Médico-Quirúrgica Enfermedades Respiratorias, Virgen del Rocío Hospital, Sevilla, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Carmen Carmona
1Unidad Médico-Quirúrgica Enfermedades Respiratorias, Virgen del Rocío Hospital, Sevilla, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Pablo Stiefel
2Unidad de Hipertensión, Virgen del Rocío Hospital, Sevilla, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Francisco Capote
1Unidad Médico-Quirúrgica Enfermedades Respiratorias, Virgen del Rocío Hospital, Sevilla, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • PDF
Loading

Abstract

Regulatory function on the vasodilatation of the maxi-K+ channel beta1 subunit has been described in mouse model.CPAP treatment was shown to be related with an increase of the beta1subunit expression.Objective: To determine the relations between oxymetric and endothelial situation and subunit beta1 expression in the moment of recruitment and after 3 month of CPAP in SAHS patients.Methods: Prospective study in SAHS patients with CPAP(3 months).SAHS was defined as an apnea-hypopnea index(AHI)≥15(cardiorespiratory polygraphy).Endothelial function was evaluated with a test of postocclusive hyperemia by Laser-Doppler flowmetry.Beta1-subunit mRNA expression was made by a blood test in peripheral blood leukocytes.This two determinations were repeated 3 months after CPAP, calculating the parameter beta1b-beta1a.Results: 33 patients were enrolled with 66,7% males.Polygraphy showed a mean AHI of 61 ± 25.8,desaturation index 60 ± 25,nocturnal saturation 89.45±4.8(%),minimum nocturnal saturation 53.87± 20.34(%) and CT90 of 31.3 ± 22.7 (%).When investigating the parameter beta1b-beta1a we found a negative correlation with: nocturnal saturation(%)(R = -0.3, p = 0.02),minimum nocturnal saturation (%) (R = -0.4, p = 0.01) and area under the curve (PU / s),(R = -0, 46, p = 0.01)and a positive correlation with CT90 (R = 0.3, p = 0.04) and the slope (PU)(R = 0.4, p = 0.001).Conclusions: In our study population individuals showing worst oxymetric parametres or basal vascular endothelial situation initially achieved after 3 month of CPAP the most important improvement of beta1 subunit levels (expressed as higher values in the difference beta1b-beta1a).

  • Apnoea / Hypopnea
  • Hypoxia
  • Biomarkers
  • © 2012 ERS
Previous
Back to top
Vol 40 Issue Suppl 56 Table of Contents
  • Table of Contents
  • Index by author
Email

Thank you for your interest in spreading the word on European Respiratory Society .

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Impact of CPAP treatment on the changes of maxi-k+ channel beta subunit-1 expression in patients affected by sleep apnea-hypopnea syndrome (SAHS)
(Your Name) has sent you a message from European Respiratory Society
(Your Name) thought you would like to see the European Respiratory Society web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Alerts
Sign In to Email Alerts with your Email Address
Citation Tools
Impact of CPAP treatment on the changes of maxi-k+ channel beta subunit-1 expression in patients affected by sleep apnea-hypopnea syndrome (SAHS)
Candela Caballero, Ángeles Sanchez Armengol, Mª. Jesús Dominguez-Simeón, María Abad, Carmen Carmona, Pablo Stiefel, Francisco Capote
European Respiratory Journal Sep 2012, 40 (Suppl 56) 3292;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Impact of CPAP treatment on the changes of maxi-k+ channel beta subunit-1 expression in patients affected by sleep apnea-hypopnea syndrome (SAHS)
Candela Caballero, Ángeles Sanchez Armengol, Mª. Jesús Dominguez-Simeón, María Abad, Carmen Carmona, Pablo Stiefel, Francisco Capote
European Respiratory Journal Sep 2012, 40 (Suppl 56) 3292;
del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo
Full Text (PDF)

Jump To

  • Article
  • Info & Metrics
  • PDF
  • Tweet Widget
  • Facebook Like
  • Google Plus One

More in this TOC Section

  • Does CPAP therapy affect sleep time in patients with obstructive sleep apnea? A prospective study
  • Axonal peripheral nerve demage in obstructive sleep apnea syndrome
  • Feasibility and patient tolerability of transcutaneous electrical stimulation in obstructive sleep apnoea
Show more 4.2 Sleep and Control of Breathing

Related Articles

Navigate

  • Home
  • Current issue
  • Archive

About the ERJ

  • Journal information
  • Editorial board
  • Reviewers
  • CME
  • Press
  • Permissions and reprints
  • Advertising

The European Respiratory Society

  • Society home
  • myERS
  • Privacy policy
  • Accessibility

ERS publications

  • European Respiratory Journal
  • ERJ Open Research
  • European Respiratory Review
  • Breathe
  • ERS books online
  • ERS Bookshop

Help

  • Feedback

For authors

  • Instructions for authors
  • Submit a manuscript
  • ERS author centre

For readers

  • Alerts
  • Subjects
  • Podcasts
  • RSS

Subscriptions

  • Accessing the ERS publications

Contact us

European Respiratory Society
442 Glossop Road
Sheffield S10 2PX
United Kingdom
Tel: +44 114 2672860
Email: journals@ersnet.org

ISSN

Print ISSN:  0903-1936
Online ISSN: 1399-3003

Copyright © 2021 by the European Respiratory Society