Skip to main content

Main menu

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • For authors
    • Instructions for authors
    • Submit a manuscript
    • Author FAQs
    • Open access
    • COVID-19 submission information
  • Alerts
  • Podcasts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • For authors
    • Instructions for authors
    • Submit a manuscript
    • Author FAQs
    • Open access
    • COVID-19 submission information
  • Alerts
  • Podcasts
  • Subscriptions

Dynamic changes of serum sTREM-1 and its gene polymorphisms associated with sepsis prognosis

Longxiang Su, Lixin Xie, Zhaoxu Jiang, Xin Zhang, Dan Feng
European Respiratory Journal 2012 40: 1360; DOI:
Longxiang Su
1Department of Respiratory Medicine, Hainan Branch of Chinese PLA General Hospital, Sanya, Hainan, China
2Department of Respiratory Medicine, Chinese PLA General Hospital, Beijing, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lixin Xie
1Department of Respiratory Medicine, Hainan Branch of Chinese PLA General Hospital, Sanya, Hainan, China
2Department of Respiratory Medicine, Chinese PLA General Hospital, Beijing, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Zhaoxu Jiang
1Department of Respiratory Medicine, Hainan Branch of Chinese PLA General Hospital, Sanya, Hainan, China
2Department of Respiratory Medicine, Chinese PLA General Hospital, Beijing, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Xin Zhang
1Department of Respiratory Medicine, Hainan Branch of Chinese PLA General Hospital, Sanya, Hainan, China
2Department of Respiratory Medicine, Chinese PLA General Hospital, Beijing, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Dan Feng
3Department of Medical Statistics, Chinese PLA General Hospital, Beijing, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • PDF
Loading

Abstract

Introduction:More and more studies have confirmed that sepsis is an acquired genetic disease. Objectives:To explore how sepsis prognosis is associated with the dynamic changes of serum sTREM-1, as well as with gene polymorphisms. Methods: 80 subjects were selected from inpatients in the RICU,SICU,and EICU. 80 healthy volunteers acted as control. To detect the dynamic changes of serum sTREM-1 over a 14-day observation, ELISA was performed. Four exons of TREM-1 gene were sequenced on ABI3730. Results: The nonsurvivors'sTREM-1 levels remain significantly higher than the survivors' over period of 14 days(P<0.01). The curves show that the nonsurvivors register higher sTREM-1 levels at the initial stage, which steadily go up with the passage of time. In contrast, the survivors'sTREM-1 levels are on the decline all the time. Three TREM-1 SNPs (rs144672509,rs2234237 and rs2234246) are detected from four exons. In three inherited models, rs2234237 is clearly related to sepsis prognosis(P<0.05). The log-rank test shows that patients with the rs2234237 genetic variation stand a greater probability of a 28-day death(P<0.05). However, no relationship is spotted between TREM-1 gene polymorphism and the dynamic concentrations of serum sTREM-1. Logistic regression analysis shows that sTREM-1,APACHE II score,and TREM-1 rs2234237 genetic variation are risk factors affecting the prognosis. Conclusions: Dynamic changes in serum sTREM-1 may be more accurate and valuable for sepsis monitoring and for dynamic assessments of prognosis. It is proved that TREM-1 rs2234237 polymorphism is associated with high 28-day mortality among sepsis patients, constituting a risk factor affecting prognosis.

  • Sepsis
  • Immunology
  • Genetics
  • © 2012 ERS
Previous
Back to top
Vol 40 Issue Suppl 56 Table of Contents
  • Table of Contents
  • Index by author
Email

Thank you for your interest in spreading the word on European Respiratory Society .

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Dynamic changes of serum sTREM-1 and its gene polymorphisms associated with sepsis prognosis
(Your Name) has sent you a message from European Respiratory Society
(Your Name) thought you would like to see the European Respiratory Society web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Alerts
Sign In to Email Alerts with your Email Address
Citation Tools
Dynamic changes of serum sTREM-1 and its gene polymorphisms associated with sepsis prognosis
Longxiang Su, Lixin Xie, Zhaoxu Jiang, Xin Zhang, Dan Feng
European Respiratory Journal Sep 2012, 40 (Suppl 56) 1360;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Dynamic changes of serum sTREM-1 and its gene polymorphisms associated with sepsis prognosis
Longxiang Su, Lixin Xie, Zhaoxu Jiang, Xin Zhang, Dan Feng
European Respiratory Journal Sep 2012, 40 (Suppl 56) 1360;
del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo
Full Text (PDF)

Jump To

  • Article
  • Info & Metrics
  • PDF
  • Tweet Widget
  • Facebook Like
  • Google Plus One

More in this TOC Section

  • Genetic homology between bacteria in pus from the pyothorax and bacteria in the oral cavity in patients with pyothorax
  • In vitro evaluation of the Twincer colistin dry powder inhaler as a non-cough-inducing alternative to Colobreathe
  • Clinical and radiological features of pneumocystis pneumonia in immunocompromised non-HIV patients
Show more 10.1 Respiratory Infections

Related Articles

Navigate

  • Home
  • Current issue
  • Archive

About the ERJ

  • Journal information
  • Editorial board
  • Reviewers
  • CME
  • Press
  • Permissions and reprints
  • Advertising

The European Respiratory Society

  • Society home
  • myERS
  • Privacy policy
  • Accessibility

ERS publications

  • European Respiratory Journal
  • ERJ Open Research
  • European Respiratory Review
  • Breathe
  • ERS books online
  • ERS Bookshop

Help

  • Feedback

For authors

  • Instructions for authors
  • Submit a manuscript
  • ERS author centre

For readers

  • Alerts
  • Subjects
  • Podcasts
  • RSS

Subscriptions

  • Accessing the ERS publications

Contact us

European Respiratory Society
442 Glossop Road
Sheffield S10 2PX
United Kingdom
Tel: +44 114 2672860
Email: journals@ersnet.org

ISSN

Print ISSN:  0903-1936
Online ISSN: 1399-3003

Copyright © 2021 by the European Respiratory Society