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Sweet talk: insights into the nature and importance of glucose transport in lung epithelium

James P. Garnett, Emma H. Baker, Deborah L. Baines
European Respiratory Journal 2012 40: 1269-1276; DOI: 10.1183/09031936.00052612
James P. Garnett
Division of Biomedical Sciences St George’s, University of London, London, UK
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Emma H. Baker
Division of Biomedical Sciences St George’s, University of London, London, UK
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Deborah L. Baines
Division of Biomedical Sciences St George’s, University of London, London, UK
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  • For correspondence: dbaines@sgul.ac.uk
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    Figure 1–

    Current model of the mechanisms controlling glucose concentrations in the surface liquid lining the airway and distal lung epithelium. a) In the airway epithelium, the glucose concentration of the airway surface liquid (ASL) is the net effect of paracellular diffusion (and, to a lesser extent, the transcellular flux of glucose) from the blood and interstitial fluid across respiratory epithelium into the ASL, and removal of glucose from ASL by uptake into epithelial cells. Glucose uptake across the apical membrane is mediated by facultative glucose transporter (GLUT)2 and GLUT10, and across the basolateral membrane by GLUT2 and GLUT1. b) In the distal (alveolar) lung epithelium, glucose uptake across the apical membrane is via sodium-coupled glucose transporter (SGLT)1 and the basolateral membrane via unidentified GLUTs.

Tables

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  • Table 1– Facultative glucose transporter (GLUT) and sodium-coupled glucose transporter (SGLT) expression in human cultured epithelial cells, human bronchial tissue and whole lung
    TransporterHuman cultured epithelial cellsBronchial tissueWhole lung
    H441HBECs
    NonpolarisedPolarised
    mRNAProteinmRNAProteinmRNAProteinmRNAProteinmRNAProtein
    GLUTs
     GLUT1+ [13]- [13]- [13]+ [11]+ [11]+ [11]- [45]+ [47]- [45, 46]
     GLUT2+ [13]+ [13]+ [10, 13]+ [11]- [11]+ [11]+ [13, 46]
     GLUT3- [13]- [13]- [13]+ [11]- [11]+ [11]- [45]+ [47]- [45, 46]
     GLUT4+ [13]+ [13]- [13]+ [11]- [11]+ [11]- [45]- [45, 46]
     GLUT5+ [11]+ [11]- [45]+ [47]- [45, 46]
     GLUT6+ [11]+ [11]
     GLUT7+ [11]+ [11]
     GLUT8+ [11]- [11]+ [11]
     GLUT9+ [11]+ [11]
     GLUT10+ [10]+ [11]+ [11]+ [11]+ [48]
     GLUT11+ [11]+ [11]
     GLUT12+ [11]+ [11]
    SGLTs
     SGLT1+ [11]- [11]+ [11]+ [49]
     SGLT2+ [11]- [11]+ [11]+ [49]
    • HBEC: human bronchial epithelial cells; +: present; -: absent.

  • Table 2– Facultative glucose transporter (GLUT) and sodium-coupled glucose transporter (SGLT) expression in whole lung, and bronchial and alveolar# epithelium in fetal and adult stages
    TransporterWhole lungBronchial epitheliumAlveolar epithelium
    FetalAdultFetalAdultFetalAdult
    RNAProteinRNAProteinRNAProteinRNAProteinRNAProteinRNAProtein
    GLUTs
     GLUT1+ [50, 51]+ [50]+ [51, 52]+ [57]
    - [58]§
    - [58]§+ [59]
    - [58]§
    + [60]- [58]§
     GLUT2+ [53]¶+ [45]- [60]
     GLUT3
     GLUT4+ [52]+ [60]
     GLUT5+ [60]
     GLUT6
     GLUT7
     GLUT8
     GLUT9
     GLUT10
     GLUT12+ [57]
    SGLTs
     SGLT1+ [54, 55] + [56]§- [45]ƒ+ [60]+ [61]
    + [61]##
     SGLT2- [60]
    • Expression in rats unless otherwise stated. +: present; -: absent. #: type II cells; ¶: pig; §: mouse; ƒ: rabbit; ##: sheep.

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Sweet talk: insights into the nature and importance of glucose transport in lung epithelium
James P. Garnett, Emma H. Baker, Deborah L. Baines
European Respiratory Journal Nov 2012, 40 (5) 1269-1276; DOI: 10.1183/09031936.00052612

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Sweet talk: insights into the nature and importance of glucose transport in lung epithelium
James P. Garnett, Emma H. Baker, Deborah L. Baines
European Respiratory Journal Nov 2012, 40 (5) 1269-1276; DOI: 10.1183/09031936.00052612
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  • Article
    • Abstract
    • NORMAL GLUCOSE CONCENTRATIONS IN AIRWAY SURFACE LIQUID
    • PROCESSES THAT DETERMINE ASL GLUCOSE CONCENTRATIONS
    • GLUCOSE DIFFUSION INTO ASL
    • THE ROLE OF GLUCOSE TRANSPORT IN LIMITING ASL GLUCOSE
    • EFFECTS OF ELEVATED ASL GLUCOSE CONCENTRATIONS
    • QUESTIONS FOR THE FUTURE
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  • Mechanisms of lung disease
  • Lung biology and experimental studies
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