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Nitric oxide in primary ciliary dyskinesia

Woolf T. Walker, Claire L. Jackson, Peter M. Lackie, Claire Hogg, Jane S. Lucas
European Respiratory Journal 2012 40: 1024-1032; DOI: 10.1183/09031936.00176111
Woolf T. Walker
*Primary Ciliary Dyskinesia Centre, NIHR Respiratory Biomedical Research Unit, Division of Infection Inflammation and Immunity, Faculty of Medicine, University of Southampton, Southampton
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Claire L. Jackson
*Primary Ciliary Dyskinesia Centre, NIHR Respiratory Biomedical Research Unit, Division of Infection Inflammation and Immunity, Faculty of Medicine, University of Southampton, Southampton
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Peter M. Lackie
*Primary Ciliary Dyskinesia Centre, NIHR Respiratory Biomedical Research Unit, Division of Infection Inflammation and Immunity, Faculty of Medicine, University of Southampton, Southampton
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Claire Hogg
#The Royal Brompton Hospital, Sydney Street, London, UK
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Jane S. Lucas
*Primary Ciliary Dyskinesia Centre, NIHR Respiratory Biomedical Research Unit, Division of Infection Inflammation and Immunity, Faculty of Medicine, University of Southampton, Southampton
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  • For correspondence: jlucas1@soton.ac.uk
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Article Information

vol. 40 no. 4 1024-1032
DOI 
https://doi.org/10.1183/09031936.00176111
PubMed 
22408195

Published By 
European Respiratory Society
Print ISSN 
0903-1936
Online ISSN 
1399-3003
History 
  • Received October 11, 2011
  • Accepted February 8, 2012
  • Published online September 30, 2012.

Article Versions

  • previous version (March 9, 2012 - 01:45).
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©ERS 2012

Author Information

  1. Woolf T. Walker*,
  2. Claire L. Jackson*,
  3. Peter M. Lackie*,
  4. Claire Hogg# and
  5. Jane S. Lucas*⇓
  1. *Primary Ciliary Dyskinesia Centre, NIHR Respiratory Biomedical Research Unit, Division of Infection Inflammation and Immunity, Faculty of Medicine, University of Southampton, Southampton
  2. #The Royal Brompton Hospital, Sydney Street, London, UK
  1. J.S. Lucas, Primary Ciliary Dyskinesia Diagnostic and Research Team (MP 803) NIHR Respiratory Biomedical Research Unit, Southampton University Hospitals NHS Trust, Tremona Road, Southampton, SO16 6YD, UK. E-mail: jlucas1{at}soton.ac.uk
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Vol 40 Issue 4 Table of Contents
European Respiratory Journal: 40 (4)
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Nitric oxide in primary ciliary dyskinesia
Woolf T. Walker, Claire L. Jackson, Peter M. Lackie, Claire Hogg, Jane S. Lucas
European Respiratory Journal Oct 2012, 40 (4) 1024-1032; DOI: 10.1183/09031936.00176111

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Nitric oxide in primary ciliary dyskinesia
Woolf T. Walker, Claire L. Jackson, Peter M. Lackie, Claire Hogg, Jane S. Lucas
European Respiratory Journal Oct 2012, 40 (4) 1024-1032; DOI: 10.1183/09031936.00176111
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  • Article
    • Abstract
    • THE BIOSYNTHESIS AND ROLE OF NITRIC OXIDE IN THE AIRWAY
    • PRIMARY CILIARY DYSKINESIA
    • DIAGNOSIS
    • SCREENING: THE ROLE OF NASAL NITRIC OXIDE
    • MEASUREMENT OF ALVEOLAR AND BRONCHIAL NITRIC OXIDE IN HEALTH AND IN PCD
    • WHY ARE NITRIC OXIDE LEVELS REDUCED IN PCD?
    • HYPOTHESIS 1: INCREASED BREAKDOWN OF NITRIC OXIDE TO METABOLITES
    • HYPOTHESIS 2: REDUCED BIOSYNTHESIS OF NITRIC OXIDE
    • HYPOTHESIS 3: NITRIC OXIDE IS TRAPPED IN THE OBSTRUCTED PARANASAL SINUSES
    • HYPOTHESIS 4: REDUCED PRODUCTION AND STORAGE CAPACITY OF NITRIC OXIDE IN THE PARANASAL SINUSES
    • THE VALUE OF AUGMENTATION OF NITRIC OXIDE LEVELS IN PCD
    • SUMMARY
    • Acknowledgments
    • Footnotes
    • REFERENCES
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