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Recommendations for epidemiological studies on COPD

Per Sigvald Bakke, Eva Rönmark, Tomas Mikal Eagan, Francesco Pistelli, Isabella Annesi-Maesano, Marek Maly, Mari Meren, Jan Zielinski, Giovanni Viegi, Bo Lundbäck
European Respiratory Journal 2012 39: 1278-1279; DOI: 10.1183/09031936.00011712
Per Sigvald Bakke
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  • For correspondence: per.bakke@med.uib.no
Eva Rönmark
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Tomas Mikal Eagan
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Francesco Pistelli
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Isabella Annesi-Maesano
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Marek Maly
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Mari Meren
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Jan Zielinski
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Giovanni Viegi
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Bo Lundbäck
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From the authors:

We thank P.H. Quanjer and co-workers for their valuable comments to our paper [1]. Chronic obstructive lung disease (COPD) is a syndrome and we welcome a debate on how to define it in an epidemiological setting.

First of all, we should state that we are in favour of forced expiratory volume in 1 s (FEV1)/(forced) vital capacity ((F)VC) ratio lower than the 5th percentile of the normal distribution as the diagnostic criterion for COPD. That is why our paper recommends this criterion for COPD in epidemiological studies [1]. However, we should acknowledge that there are controversies on this topic. For the sake of completeness, the study by Mannino et al. [2] was cited. We agree that Mannino et al. [2] showed that the age-adjusted hazard ratio of mortality of those with an FEV1/FVC <0.7 and greater than the 5th percentile of the FEV1/FVC ratio did not reach the level of significance when compared to those with an FEV1/FVC >0.7. However, they also showed that there is a clear dose–response relationship, with increasing hazard ratios of mortality with decreasing FEV1/FVC, the reference being an FEV1/FVC >0.7. An FEV1/FVC <0.70 may be considered a risk factor for the development of COPD as diagnosed by an FEV1/VC less than the lower limit of normal [3].

As to the question of using a bronchodilator prior to spirometry in epidemiological studies, we think that the criteria for COPD used in epidemiological studies should be the same as in the clinical setting, in which post-bronchodilator spirometry is recommended. This will enhance interpretation and comparison between studies as well as communication with politicians and healthcare providers. Spirometric reference values based on post-bronchodilator values are already available [4].

If the research question also relates to reversibility, then both pre- and post-bronchodilatory spirometry should be performed. Studies show that it is not only the level of FEV1/(F)VC that may differ between pre- and post-bronchodilator values of the ratio, but also the observed risk factor–disease relationships, especially those related to age and smoking [5]. The potential risks of inhaling a β-agonist in the recommended doses are negligible [6].

We acknowledge that there is the possibility that some subjects choose to abstain from participating in an epidemiological study because they do not want to inhale the medication. However, in a Norwegian community sample aged 18–73 yrs, this figure was only 3%. The characteristics of the nonresponders in this study did not differ overtly from those seen in other studies [5, 7, 8]. As to the cost, our experience is that the cost, in both time and money, of using a short-acting bronchodilator is very modest compared with the total cost of running a community study on COPD.

As shown by both our report and the comments of P.H. Quanjer and co-workers, there are several methodological questions related to the diagnostic criteria of COPD. This clearly points to the need for further epidemiological surveys on COPD.

  • ©ERS 2012

REFERENCES

  1. ↵
    1. Bakke PS,
    2. Rönmark E,
    3. Eagan T,
    4. et al
    . Recommendations for epidemiological studies on COPD. Eur Respir J 2011; 38: 1261–1277.
    OpenUrlAbstract/FREE Full Text
  2. ↵
    1. Mannino DM,
    2. Buist AS,
    3. Vollmer WM
    . Chronic obstructive pulmonary disease in the older adult: what defines abnormal lung function? Thorax 2007; 62: 237–241.
    OpenUrlAbstract/FREE Full Text
  3. ↵
    1. Viegi G,
    2. Pedreschi M,
    3. Pistelli F,
    4. et al
    . Prevalence of airways obstruction in a general population: European Respiratory Society vs American Thoracic Society definition. Chest 2000; 117: Suppl. 2, 339S–345S.
    OpenUrlCrossRefPubMedWeb of Science
  4. ↵
    1. Johannessen A,
    2. Lehmann S,
    3. Omenaas ER,
    4. et al
    . Post-bronchodilator spirometry reference values in adults and implications for disease management. Am J Respir Crit Care Med 2006; 173: 1316–1325.
    OpenUrlCrossRefPubMedWeb of Science
  5. ↵
    1. Johannessen A,
    2. Omenaas ER,
    3. Bakke PS,
    4. et al
    . Implications of reversibility testing on prevalence and risk factors for chronic obstructive pulmonary disease: a community study. Thorax 2005; 60: 842–847.
    OpenUrlAbstract/FREE Full Text
  6. ↵
    1. Lehmann S,
    2. Vollset SE,
    3. Nygaard HA,
    4. et al
    . Factors determining performance of bronchodilator reversibility tests in middle-aged and elderly. Respir Med 2004; 98: 1071–1079.
    OpenUrlCrossRefPubMedWeb of Science
  7. ↵
    1. Rönmark EP,
    2. Ekerljung L,
    3. Lötvall J,
    4. et al
    . Large scale questionnaire survey on respiratory health in Sweden: effects of late- and non-response. Respir Med 2009; 103: 1807–1815.
    OpenUrlCrossRefPubMedWeb of Science
  8. ↵
    1. Verlato G,
    2. Melotti R,
    3. Olivieri M,
    4. et al
    . Asthmatics and ex-smokers respond early, heavy smokers respond late to mailed surveys in Italy. Respir Med 2010; 104: 172–179.
    OpenUrlCrossRefPubMed
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Recommendations for epidemiological studies on COPD
Per Sigvald Bakke, Eva Rönmark, Tomas Mikal Eagan, Francesco Pistelli, Isabella Annesi-Maesano, Marek Maly, Mari Meren, Jan Zielinski, Giovanni Viegi, Bo Lundbäck
European Respiratory Journal May 2012, 39 (5) 1278-1279; DOI: 10.1183/09031936.00011712

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Recommendations for epidemiological studies on COPD
Per Sigvald Bakke, Eva Rönmark, Tomas Mikal Eagan, Francesco Pistelli, Isabella Annesi-Maesano, Marek Maly, Mari Meren, Jan Zielinski, Giovanni Viegi, Bo Lundbäck
European Respiratory Journal May 2012, 39 (5) 1278-1279; DOI: 10.1183/09031936.00011712
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