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Effect of proteinase inhibitor from crataeva tapia (cratabl) in distal lung mechanical, inflammatory and remodeling alterations induced by elastase in mice

Leandro V. Oliva, Rafael Almeida-Reis, Osmar Theodoro Jr., Bruno Tadeu Martins-Oliveira, Clarice R. Olivo, Tales V. Lopes, Alessandra C. Toledo, Rodrigo S. Ferreira, Marlon V. Brito, Milton A. Martins, Maria L.V. Oliva, Iolanda F.L.C. Tiberio
European Respiratory Journal 2011 38: p817; DOI:
Leandro V. Oliva
1Clinical Medicine, School of Medicne University of Sao Paulo, Sao Paulo, Brazil
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Rafael Almeida-Reis
1Clinical Medicine, School of Medicne University of Sao Paulo, Sao Paulo, Brazil
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Osmar Theodoro Jr.
1Clinical Medicine, School of Medicne University of Sao Paulo, Sao Paulo, Brazil
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Bruno Tadeu Martins-Oliveira
1Clinical Medicine, School of Medicne University of Sao Paulo, Sao Paulo, Brazil
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Clarice R. Olivo
1Clinical Medicine, School of Medicne University of Sao Paulo, Sao Paulo, Brazil
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Tales V. Lopes
1Clinical Medicine, School of Medicne University of Sao Paulo, Sao Paulo, Brazil
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Alessandra C. Toledo
1Clinical Medicine, School of Medicne University of Sao Paulo, Sao Paulo, Brazil
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Rodrigo S. Ferreira
2Biochemistry, Federal University of Sao Paulo, Sao Paulo, Brazil
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Marlon V. Brito
2Biochemistry, Federal University of Sao Paulo, Sao Paulo, Brazil
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Milton A. Martins
1Clinical Medicine, School of Medicne University of Sao Paulo, Sao Paulo, Brazil
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Maria L.V. Oliva
2Biochemistry, Federal University of Sao Paulo, Sao Paulo, Brazil
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Iolanda F.L.C. Tiberio
1Clinical Medicine, School of Medicne University of Sao Paulo, Sao Paulo, Brazil
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Abstract

Aims: The leading role of elastase in the emphysema physiopathology has been recognized. The present study aimed to evaluate if a plant proteinase inhibitor CratabL contributes to inactivation of elastase-induced mechanical, inflammatory and extracellular matrix remodelling alterations.

Methods: C57Bl6 mice received elastase intranasally (50ml/animal E group). Control group received saline (Ve group). Afterwards, mice were treated with CratabL (2mg/kg) at days 1, 15, 21, 28, 35 after elastase instillation (I-E group). At day 40, mice were anesthetized and mechanically ventilated and we analyzed respiratory system resistance and elastance, tissue elastance, tissue damping and airway resistance. Afterwards, BAL was performed and lungs were removed. By morphometry, we quantified the mean linear intercept (Lm) and the collagen and elastic fibers in distal lung parenchyma.

Results: We did not observe any differences in pulmonary mechanics comparing all groups. In E group, there was an increase in BAL-total cells, BAL-lymphocytes, BAL-neutrophils, collagen and elastic fibers and Lm compared to Ve group (p<0.05). The CratabL treatment in elastase treated animals decreased Lm (105.9±10.0μm) compared to E group (p<0.05). BAL-neutrophils (7.2±1.4×104cells/mL), and collagen content (0.59±0.02%) were decreased in I-E group compared to E animals (p<0.05).

Conclusions: This plant proteinase inhibitor (CratabL) reduced elastase-induced pulmonary inflammatory and remodeling alterations which may be considered as a new and potential therapeutic strategy for COPD treatment.

Financial support: FAPESP, CNPq, LIM- HCFMUSP.

  • © 2011 ERS
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Effect of proteinase inhibitor from crataeva tapia (cratabl) in distal lung mechanical, inflammatory and remodeling alterations induced by elastase in mice
Leandro V. Oliva, Rafael Almeida-Reis, Osmar Theodoro, Bruno Tadeu Martins-Oliveira, Clarice R. Olivo, Tales V. Lopes, Alessandra C. Toledo, Rodrigo S. Ferreira, Marlon V. Brito, Milton A. Martins, Maria L.V. Oliva, Iolanda F.L.C. Tiberio
European Respiratory Journal Sep 2011, 38 (Suppl 55) p817;

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Effect of proteinase inhibitor from crataeva tapia (cratabl) in distal lung mechanical, inflammatory and remodeling alterations induced by elastase in mice
Leandro V. Oliva, Rafael Almeida-Reis, Osmar Theodoro, Bruno Tadeu Martins-Oliveira, Clarice R. Olivo, Tales V. Lopes, Alessandra C. Toledo, Rodrigo S. Ferreira, Marlon V. Brito, Milton A. Martins, Maria L.V. Oliva, Iolanda F.L.C. Tiberio
European Respiratory Journal Sep 2011, 38 (Suppl 55) p817;
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