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LSC 2011 Abstract: BAFF in the interaction between T regulatory and B cells in COPD

Francesca Polverino, Jaime Pons, Amanda Iglesias, Angel Rios, Sergio Scrimini, Catalina Crespi, Jaume Sauleda, Alvar Agusti, Borja Cosio
European Respiratory Journal 2011 38: p740; DOI:
Francesca Polverino
Unidad de Investigacion, Hospital Son Dureta, Palma de Mallorca, Islas Baleares, ES Fundacion Caubet-Cimera, Unidad de Investigacion HUSD, Palma de Mallorca, Islas Baleares, ES Respiratory Diseases, Ciber, Palma de Mallorca, Islas Baleares, ES Respiratory Medicine, Hospital Son Dureta, Palma de Mallorca, Islas Baleares, ES Hospital Clinic, Instituto del Tόrax, Barcelona, ES Respiratory Patophysiology, University of Messina, Messina, IT
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Jaime Pons
Unidad de Investigacion, Hospital Son Dureta, Palma de Mallorca, Islas Baleares, ES Fundacion Caubet-Cimera, Unidad de Investigacion HUSD, Palma de Mallorca, Islas Baleares, ES Respiratory Diseases, Ciber, Palma de Mallorca, Islas Baleares, ES Respiratory Medicine, Hospital Son Dureta, Palma de Mallorca, Islas Baleares, ES Hospital Clinic, Instituto del Tόrax, Barcelona, ES Respiratory Patophysiology, University of Messina, Messina, IT
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Amanda Iglesias
Unidad de Investigacion, Hospital Son Dureta, Palma de Mallorca, Islas Baleares, ES Fundacion Caubet-Cimera, Unidad de Investigacion HUSD, Palma de Mallorca, Islas Baleares, ES Respiratory Diseases, Ciber, Palma de Mallorca, Islas Baleares, ES Respiratory Medicine, Hospital Son Dureta, Palma de Mallorca, Islas Baleares, ES Hospital Clinic, Instituto del Tόrax, Barcelona, ES Respiratory Patophysiology, University of Messina, Messina, IT
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Angel Rios
Unidad de Investigacion, Hospital Son Dureta, Palma de Mallorca, Islas Baleares, ES Fundacion Caubet-Cimera, Unidad de Investigacion HUSD, Palma de Mallorca, Islas Baleares, ES Respiratory Diseases, Ciber, Palma de Mallorca, Islas Baleares, ES Respiratory Medicine, Hospital Son Dureta, Palma de Mallorca, Islas Baleares, ES Hospital Clinic, Instituto del Tόrax, Barcelona, ES Respiratory Patophysiology, University of Messina, Messina, IT
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Sergio Scrimini
Unidad de Investigacion, Hospital Son Dureta, Palma de Mallorca, Islas Baleares, ES Fundacion Caubet-Cimera, Unidad de Investigacion HUSD, Palma de Mallorca, Islas Baleares, ES Respiratory Diseases, Ciber, Palma de Mallorca, Islas Baleares, ES Respiratory Medicine, Hospital Son Dureta, Palma de Mallorca, Islas Baleares, ES Hospital Clinic, Instituto del Tόrax, Barcelona, ES Respiratory Patophysiology, University of Messina, Messina, IT
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Catalina Crespi
Unidad de Investigacion, Hospital Son Dureta, Palma de Mallorca, Islas Baleares, ES Fundacion Caubet-Cimera, Unidad de Investigacion HUSD, Palma de Mallorca, Islas Baleares, ES Respiratory Diseases, Ciber, Palma de Mallorca, Islas Baleares, ES Respiratory Medicine, Hospital Son Dureta, Palma de Mallorca, Islas Baleares, ES Hospital Clinic, Instituto del Tόrax, Barcelona, ES Respiratory Patophysiology, University of Messina, Messina, IT
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Jaume Sauleda
Unidad de Investigacion, Hospital Son Dureta, Palma de Mallorca, Islas Baleares, ES Fundacion Caubet-Cimera, Unidad de Investigacion HUSD, Palma de Mallorca, Islas Baleares, ES Respiratory Diseases, Ciber, Palma de Mallorca, Islas Baleares, ES Respiratory Medicine, Hospital Son Dureta, Palma de Mallorca, Islas Baleares, ES Hospital Clinic, Instituto del Tόrax, Barcelona, ES Respiratory Patophysiology, University of Messina, Messina, IT
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Alvar Agusti
Unidad de Investigacion, Hospital Son Dureta, Palma de Mallorca, Islas Baleares, ES Fundacion Caubet-Cimera, Unidad de Investigacion HUSD, Palma de Mallorca, Islas Baleares, ES Respiratory Diseases, Ciber, Palma de Mallorca, Islas Baleares, ES Respiratory Medicine, Hospital Son Dureta, Palma de Mallorca, Islas Baleares, ES Hospital Clinic, Instituto del Tόrax, Barcelona, ES Respiratory Patophysiology, University of Messina, Messina, IT
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Borja Cosio
Unidad de Investigacion, Hospital Son Dureta, Palma de Mallorca, Islas Baleares, ES Fundacion Caubet-Cimera, Unidad de Investigacion HUSD, Palma de Mallorca, Islas Baleares, ES Respiratory Diseases, Ciber, Palma de Mallorca, Islas Baleares, ES Respiratory Medicine, Hospital Son Dureta, Palma de Mallorca, Islas Baleares, ES Hospital Clinic, Instituto del Tόrax, Barcelona, ES Respiratory Patophysiology, University of Messina, Messina, IT
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Abstract

Background: COPD shares some features with autoimmune diseases, such as a blunted regulatory T-cell (Tregs) activity allowing autoimmune reactions. B cell Activating Factor (BAFF) is a key factor modulating B cell homeostasis, and is overexpressed in B-cells lymphoid follicles of lungs from COPD patients. We hypothesize that BAFF upregulation in B cells is due to a reduced activity of TRegs translated as a lower production of BAFF in these cells.

Methods: BAFF expression in B-lymphocytes and Tregs from bronchoalveolar lavage (BAL) and blood was quantified by Flow Cytometry in 38 patients with COPD (mean±SD,FEV1=68±14%pred); 17 smokers with normal lung function (SC) (FEV1=104±15%pred) and 20 non-smokers (NSC) (FEV1=101±20%pred).

Results: In BAL, Tregs from COPD patients showed lower BAFF expression (Median, Range: 7, 0-32 Mean Fluorescence, MF) as compared to SC (17, 10-27; p=2×10-4) and NSC (14, 10-22; p=0,005).

Conversely, BAFF was overexpressed in B lymphocytes from COPD patients (50, 23-121) when compared to SC (12, 0-28; p=6×10-5) and NSC (20, 6-95; p=0,001).

In blood, COPD had less Baff+ TRegs (10, 0-22,5) and more Baff+ B lymphocytes (23, 5,6-102) compared to NSC(12, 10-5; 13, 10-53; p=0,01; p=0,006, respectively). To test whether cigarette smoke (CS) influences BAFF expression, we cultivated blood mononuclear cells from 4 NSC with 3% and 7%CS. At 24 hours, BAFF was increased in B lymphocytes stimulated with CS 3% and even more with CS 7% with respect to the control (p=0,03; p=0,02, respectively).

Conclusion: In COPD there is a blunted expression of BAFF in TRegs that leads, partly due to cigarette smoke, to its excessive production by B lymphocytes, showing an imbalance of its functioning that is a common feature of several autoimmune diseases.

  • © 2011 ERS
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LSC 2011 Abstract: BAFF in the interaction between T regulatory and B cells in COPD
Francesca Polverino, Jaime Pons, Amanda Iglesias, Angel Rios, Sergio Scrimini, Catalina Crespi, Jaume Sauleda, Alvar Agusti, Borja Cosio
European Respiratory Journal Sep 2011, 38 (Suppl 55) p740;

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LSC 2011 Abstract: BAFF in the interaction between T regulatory and B cells in COPD
Francesca Polverino, Jaime Pons, Amanda Iglesias, Angel Rios, Sergio Scrimini, Catalina Crespi, Jaume Sauleda, Alvar Agusti, Borja Cosio
European Respiratory Journal Sep 2011, 38 (Suppl 55) p740;
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