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The relation between the inflamatory mediators, quality of life, and classification of the Gold guidelines of COPD patients

Emad Ibrahim, Mohamed Zidan
European Respiratory Journal 2011 38: p548; DOI:
Emad Ibrahim
Chest Department, Alexandria University Faculty of Medicine, Alexandria, Egypt
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Mohamed Zidan
Chest Department, Alexandria University Faculty of Medicine, Alexandria, Egypt
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Abstract

Study objective: To assess the health-related quality of life (HRQL) of COPD and both the degree of severity and inflammation.

Design: Cross-sectional study.

Setting: Large, tertiary care, Alexandria university teaching hospital.

Patients: Thirty patients with COPD (mean age, 60.7 years; mean FEV1, 70.8% of predicted; mean FEV1/FVC 59.1% of predicted;PaO2, 70.7 mm Hg).

Methods: Patients underwent pulmonary function testing to assess physiologic function and the degree of respiratory impairment. A baseline dyspnea index (BDI) was used to determine levels of dyspnea, and a 6-min walk test was performed to evaluate physical and exercise capacity. The St. George Respiratory Questionnaire (SGRQ) was used to assess quality of life. Inflammatory mediators including: tumour necrosis factor, interlukin-6, and c-reactive proteins were measured.

Results: The score on the SGRQ mean was57.5. Inflammatory mediators mean: tumour necrosis factor was 4.5, interlukin-6 was 5.9, and c-reactive proteins was 11.8. Mild COPD patients were 33.3%, Moderate were 23.3%, severe 26.7%, and very severe were 16.7%. Mean 6-min walk test was 55.2 m. Mean BMI was 25.1.Patients showed a trend toward worse scores on most dimensions of the SGRQ as the severity of COPD increase (P<0.001). Differences between groups severity and HRQL and inflammatory mediators were only We found statistically significant relations for level of severity of COPD and: SGRQ (P=0.03), six minute walking test (P=0.04), and TNF (P=0.001).

Conclusions: The HRQL of patients with COPD was markedly impaired, with more pronounced impairment of functions. The severity of COPD was a significant predictor of increased TNF.

  • © 2011 ERS
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The relation between the inflamatory mediators, quality of life, and classification of the Gold guidelines of COPD patients
Emad Ibrahim, Mohamed Zidan
European Respiratory Journal Sep 2011, 38 (Suppl 55) p548;

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The relation between the inflamatory mediators, quality of life, and classification of the Gold guidelines of COPD patients
Emad Ibrahim, Mohamed Zidan
European Respiratory Journal Sep 2011, 38 (Suppl 55) p548;
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