Abstract
The link between COPD and atheroscleros (AS) has been speculated but such information at clinical features of COPD and its relation to AS is limited. To evaluate subclinic AS in patients with COPD 33 male COPD patients and 15 healthy male control subjects included the study. Subjects with exacerbation, DM, chronic renal failure, cardiac diseases excluded. All the subject underwent spirometry, blood sampling, carotid artery USG,24 hour oxygen saturation recording via a holteroxymeter. We determined carotid artery intima-media thickness (CAIMT) as indicator of subclinical AS.
Mean CAIMT was greater in COPD group (p=0.005)
Table 1. Subject characteristics
Table 2. Pearson's corralation of all subjects forCAIMT and other variables
Multivariate stepwise analysis showed significant associations between CAIMT and decreased % FEV1 (p=0.018) and between systolic BP (p=0.004) independent of age, BMI, duration of illness, diastolic BP, % FVC, CRP, T90%. Although the duration of COPD, T90% and CRP correlated with CAIMT, impaired lung function and severity of systolic blood pressure the predict CAIMT.
- © 2011 ERS
