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The subclinical atherosclerosis and its association to clinical features of stable COPD

Ozlem Salman Sever, Isik Conkbayir, Melike Yuce Ege, Serap Akcali, Hikmet Firat, Tugba Kaplan, Sadik Ardic
European Respiratory Journal 2011 38: p546; DOI:
Ozlem Salman Sever
1Pulmonary Disease Clinic, Ministery of Health Diskapi Y.B.Training and Research Hospital, Ankara, Turkey
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Isik Conkbayir
2Radiology Department, Ministery of Health Diskapi Y.B.Training and Research Hospital, Ankara, Turkey
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Melike Yuce Ege
1Pulmonary Disease Clinic, Ministery of Health Diskapi Y.B.Training and Research Hospital, Ankara, Turkey
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Serap Akcali
1Pulmonary Disease Clinic, Ministery of Health Diskapi Y.B.Training and Research Hospital, Ankara, Turkey
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Hikmet Firat
1Pulmonary Disease Clinic, Ministery of Health Diskapi Y.B.Training and Research Hospital, Ankara, Turkey
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Tugba Kaplan
1Pulmonary Disease Clinic, Ministery of Health Diskapi Y.B.Training and Research Hospital, Ankara, Turkey
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Sadik Ardic
1Pulmonary Disease Clinic, Ministery of Health Diskapi Y.B.Training and Research Hospital, Ankara, Turkey
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Abstract

The link between COPD and atheroscleros (AS) has been speculated but such information at clinical features of COPD and its relation to AS is limited. To evaluate subclinic AS in patients with COPD 33 male COPD patients and 15 healthy male control subjects included the study. Subjects with exacerbation, DM, chronic renal failure, cardiac diseases excluded. All the subject underwent spirometry, blood sampling, carotid artery USG,24 hour oxygen saturation recording via a holteroxymeter. We determined carotid artery intima-media thickness (CAIMT) as indicator of subclinical AS.

Mean CAIMT was greater in COPD group (p=0.005)

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Table 1. Subject characteristics

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Table 2. Pearson's corralation of all subjects forCAIMT and other variables

Multivariate stepwise analysis showed significant associations between CAIMT and decreased % FEV1 (p=0.018) and between systolic BP (p=0.004) independent of age, BMI, duration of illness, diastolic BP, % FVC, CRP, T90%. Although the duration of COPD, T90% and CRP correlated with CAIMT, impaired lung function and severity of systolic blood pressure the predict CAIMT.

  • © 2011 ERS
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The subclinical atherosclerosis and its association to clinical features of stable COPD
Ozlem Salman Sever, Isik Conkbayir, Melike Yuce Ege, Serap Akcali, Hikmet Firat, Tugba Kaplan, Sadik Ardic
European Respiratory Journal Sep 2011, 38 (Suppl 55) p546;

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The subclinical atherosclerosis and its association to clinical features of stable COPD
Ozlem Salman Sever, Isik Conkbayir, Melike Yuce Ege, Serap Akcali, Hikmet Firat, Tugba Kaplan, Sadik Ardic
European Respiratory Journal Sep 2011, 38 (Suppl 55) p546;
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