Abstract
Background: As a result of decrease in functional activity of T helper type 1 lymphocytes patients with asthma are predisposed to Chlamydia trachomathis (ChT) infection.
Objective: The aim of this study was to reveal the prevalence of ChT infection among asthma sick women and its influence on women reproductive health.
Methods: 44 asthmatic women aged from 17 to 45 years and 20 matched healthy women participated in the study. All were submitted to detailed clinical history, gynecologic examination and ultrasound of reproductive organs. Specific IgG, IgA and IgM antibodies were defined in serum by enzyme-linked immunosorbent assay. Research of antigenes to ChT in cervical smears was spent by polymerase chain reaction.
Results: A diagnostic titer of IgG antibodies to ChT was defined in 29,5% (13) asthmatic women and in 10,0% (2) healthy women. 53,8% (7) from 13 positive to ChT infection patients had the raised titers of IgG and IgA antibodies simultaneously. Antigenes to ChT have been revealed in cervical smears in 18,2% (8) asthmatic women and in 5,0% (1) healthy women. In ChT infected asthmatic women, in comparison with the patients without ChT infection and with the control, the increase in prevalence of chronic inflammatory diseases of uterus and ovaries (46,2±13,8% vs 12,9±6,0% and 20,0±8,9%), colpitis (53,8±13,2% vs 22,6±7,5% and 20,0±8,9%) and dysfunctional uterine bleedings (53,8±13,2% vs 6,45±4,4% and 10,0±6,7%) was marked.
Conclusion: Reproductive aged asthma sick women should be examined for an exception of ChT infection.
- © 2011 ERS