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Exercise pathophysiology in patients with chronic mountain sickness

Herman Groepenhoff, Mart Van der Plas, Sophia Beloka, Vitalie Faoro, Marieke Overbeek, Fransico Villafuerte, Robert Naeije
European Respiratory Journal 2011 38: p4744; DOI:
Herman Groepenhoff
1Pulmonolgy, VU University Medical Center, Amsterdam, Netherlands
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Mart Van der Plas
2Pulmonolgy, OLVG, Amsterdam, Netherlands
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Sophia Beloka
3Kinesiology, Free University, Erasme, Brussels, Belgium
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Vitalie Faoro
3Kinesiology, Free University, Erasme, Brussels, Belgium
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Marieke Overbeek
1Pulmonolgy, VU University Medical Center, Amsterdam, Netherlands
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Fransico Villafuerte
4Physiology, University, Lima, Peru
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Robert Naeije
5Physiology, Free University, Erasme, Brussels, Belgium
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Abstract

Introduction: Patients with chronic mountain sickness (CMS) are characterized by excessive erythrocytosis, severe hypoxemia and occasionally pulmonary hypertension, that may lead to exercise limitation. However, cardio-pulmonary exercise test (CPET) parameters in this patient group have not been established yet.

Methods: 12 CMS, 14 healthy high- (HH) and 10 lowlanders (LL) were included to perform a maximal CPET. CMS and HH performed their test at 4350m above sea level (Cerro de Pasco, Peru). LL also underwent CPET at sea level.

Results: CMS compared to HH and LL at sea level reached the same VO2max but decreased SpO2. However CMS had increased haemoglobin (HB). VE/VCO2 slope was decreased in CMS compared to HH and LL at altitude but not different from sea level LL (table 1). Figure 1 shows that the ventilatory response to exercise, was decreased in CMS compared to HH and LL at altitude (p<0.001) but not different from sea level LL.

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Conclusion: Patients with CMS have a preserved aerobic capacity with a ventilatory response identical to LL at sea level but blunted ventilatory adaptation compared to HH and LL at altitude likely explained by preserved oxygen delivery because of increased hemoglobine. This study was supported by a grant from Pfizer

  • © 2011 ERS
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Exercise pathophysiology in patients with chronic mountain sickness
Herman Groepenhoff, Mart Van der Plas, Sophia Beloka, Vitalie Faoro, Marieke Overbeek, Fransico Villafuerte, Robert Naeije
European Respiratory Journal Sep 2011, 38 (Suppl 55) p4744;

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Exercise pathophysiology in patients with chronic mountain sickness
Herman Groepenhoff, Mart Van der Plas, Sophia Beloka, Vitalie Faoro, Marieke Overbeek, Fransico Villafuerte, Robert Naeije
European Respiratory Journal Sep 2011, 38 (Suppl 55) p4744;
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