Abstract
There are good results in locally advanced non-small cell lung carcinoma (NSCLC) surgically treated after induction therapy. We aimed to detect the role of PET-CT on recurrence, survival and preoperative assessment in surgically treated pT0-T1N0M0 after induction therapy.
Of the patients, stage IIB, IIIA and IIIB NSCLC, undergone pulmonary resection after neoadjuvant chemotherapy or radiotherapy, pT0N0 and pT1N0 were included.
There were 54 patients with an average age of 59.2 years, 25 pT0N0 and 29 pT1N0. The median follow up was 34.8 months where mean survival time and 5-year survival rate were 90.8 months and 86.3%, 62.6 months and 53.7% (p= 0.1), respectively. There were one (4%) local recurrence in T0 and eight (27.6%) (3 local, 4 distant and one local plus distant) in T1 (p=0.03). 18 patients preoperatively assessed with PET-CT, the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were 78%, 56%, 64% and 71%. NPV in T0 and PPV in T1 were 100%. The accuracy in T0 and T1 were 56% and 78% (p=0.3).
The survival of the pT0N0 and pT1N0 NSCLC who had surgical resection after induction therapy are similar with those had resection without induction. The success of PET-CT to reveal pT0, with no live tumor cell, and pT1 preoperatively, is lower.
- © 2011 ERS
