Abstract
Aim: To investigate biochemical parameters of sputum for evaluation of MCC's disorders in patients with COPD.
Materials: 90 smoking patients with COPD in stable condition.
Methods: Biochemical parameters of sputum (medium weight molecules (MWM), trypsin, cysteine proteases cathepsin B, cathepsin L, α1-proteinase inhibitor (α1-PI)) were researched for MCC's evaluation.
Results: Dynamics of indices are in table 1.
Conclusions: Bronchial obstruction progression accompanied by decreasing of local proteolytic potential of sputum: trypsin (r= -0,61, p<0,001); cathepsin B (r= -0,42, p<0,01); cathepsin L (r=0,39, p<0,01); α1-PI (r=0,39, p<0,01). It leads to decreasing of sputum lysis and accumulation of hyperviscosity mucus in respiratory tract. As a result, movement of ciliary epithelium is blocked.
Decreasing of sputum lytic properties accompanied by accumulation of MWM (correlation between severity of COPD and MWM level – r=0,60, p<0,001). It also enhances the viscosity of sputum and violates the optimal conditions of MCC functioning.
So, bronchial obstruction progression in patients with COPD accompanied by decreasing of common lytic activity of sputum, therefore excessive amount of viscous bronchial secretion accumulate. It slows down ciliary epithelium movement, compounding the disorders of MCC.
- © 2011 ERS