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How does obesity correlate with severe asthma?

David Gibeon, Winston Banya, Hofmann Markus, Regan Suzanne, Pankaj Bhavsar, Kian Fan Chung, Andrew Menzies-Gow
European Respiratory Journal 2011 38: p4009; DOI:
David Gibeon
National Heart & Lung Institute, Royal Brompton Hospital, London, United Kingdom
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Winston Banya
National Heart & Lung Institute, Royal Brompton Hospital, London, United Kingdom
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Hofmann Markus
National Heart & Lung Institute, Royal Brompton Hospital, London, United Kingdom
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Regan Suzanne
National Heart & Lung Institute, Royal Brompton Hospital, London, United Kingdom
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Pankaj Bhavsar
National Heart & Lung Institute, Royal Brompton Hospital, London, United Kingdom
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Kian Fan Chung
National Heart & Lung Institute, Royal Brompton Hospital, London, United Kingdom
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Andrew Menzies-Gow
National Heart & Lung Institute, Royal Brompton Hospital, London, United Kingdom
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Abstract

Introduction: 10% of asthmatics have refractory disease. Cluster analysis has identified that BMI is a factor in defining phenotypes of severe asthma [1]. Obesity antedates asthma diagnosis [2], suggesting that obesity has a pathophysiological role.

Last year we reported the outcome of 115 patients with severe, treatment refractory asthma (ATS, 2000). This study looks at data from 374 patients from 4 UK centres, collected as part of the National Registry for dedicated UK Difficult Asthma Services.

Methods: Patients were divided into three groups by BMI: 18.5 to 24.99, 25 to 29.99 (overweight), and ≥30 (obese).

Results: The table below highlights demographic data, lung function, steroid use and bone density between groups.

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Table 1. Obesity and severe asthma

Conclusion: Severe asthmatics are more likely to be female although this does not appear to correlate to BMI. Raised BMI is associated with more GORD, greater use of PPI's, increased KCO, but a reduction in aspirin sensitivity, and appears to be protective against osteoporosis at the neck of femur.

References:

  • 1. Moore W, et al. Identification of asthma phenotypes using cluster analysis in the severe asthma research program. AJCCM 2009 epub ahead of print.

  • 2. Shore SA. Obesity and asthma: cause for concern. Current Opinion in Pharmacology 2006;6:230-236.

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    How does obesity correlate with severe asthma?
    David Gibeon, Winston Banya, Hofmann Markus, Regan Suzanne, Pankaj Bhavsar, Kian Fan Chung, Andrew Menzies-Gow
    European Respiratory Journal Sep 2011, 38 (Suppl 55) p4009;

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    How does obesity correlate with severe asthma?
    David Gibeon, Winston Banya, Hofmann Markus, Regan Suzanne, Pankaj Bhavsar, Kian Fan Chung, Andrew Menzies-Gow
    European Respiratory Journal Sep 2011, 38 (Suppl 55) p4009;
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