Skip to main content

Main menu

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • COVID-19 submission information
    • Peer reviewer login
  • Alerts
  • Podcasts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • COVID-19 submission information
    • Peer reviewer login
  • Alerts
  • Podcasts
  • Subscriptions

Osteopontin and soluble mesothelin-related peptide levels in malignant and benign diseases due to environmental asbestos exposure and healthy people with environmental asbestos exposure

Mehmet Bayram, Isa Döngel, Ali Akbas, Nur Dilek Bakan, Ismail Benli
European Respiratory Journal 2011 38: p3317; DOI:
Mehmet Bayram
1Chest Disease, Sivas Numune Hospital, Sivas, Turkey
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Isa Döngel
2Thoracic Surgery, Sivas Numune Hospital, Sivas, Turkey
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ali Akbas
3Biochemistry, Sivas State Hospital, Sivas, Turkey
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nur Dilek Bakan
4Chest Disease, Yedikule Teaching Hospital for Chest Dieases and Thoracic Surgery, Istanbul, Turkey
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ismail Benli
5Biochemistry, Gaziosmanpasa Universitiy Medicine School, Tokat, Turkey
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
Loading

Abstract

Objective: To determine osteopontin and soluble mesothelin-related peptide (SMRP) levels in malignant mesothelioma (MM) patients, in subjects with pleural plaques (PP) due to environmental asbestos exposure and in healthy subjects with environmental asbestos exposure.

Methods: Blood samples were taken from 279 residents from villages close to ophiolitic units (OU) (serpentin asbest containing) with PP on chest X-ray, 123 healthy subjects from villages close to OU, 120 healthy subjects from villages >26 km distant to OU and 24 MM patients.

Results: Mean serum osteopontin levels for MM, PP, asbestos-exposed healthy subjects and healthy subjects not exposed to asbestos were 21.207, 8.956, 9.453 and 9.725 ng/L respectively. Mean serum SMRP levels for MM, PP, asbestos-exposed healthy subjects and healthy subjects not exposed to asbestos were 4.59, 1.10, 1.11 and 1.12 ng/L respectively. Mean levels of both biomarkers were significantly higher in MM patients. The comparisons of biomarkers levels between the other three groups revealed no significant difference. Area under ROC curve was 0.86, sensitivity 75%, specificity 86% for osteopontin (cutoff value:17.273 ng/L) detecting MM. Area under ROC curve was 0.75, sensitivity 58%, specificity 83% for SMRP (cutoff value:1.63 ng/L) detecting MM. No difference was found between the areas under ROC curves of the two biomarkers in the diagnosis of MM.

Conclusion: Osteopontin and SMRP levels are higher in MM patients than in subjects with PP and healthy subjects with environmental asbestos exposure. The two biomarkers have no superiority to each other.

  • © 2011 ERS
Previous
Back to top
Vol 38 Issue Suppl 55 Table of Contents
  • Table of Contents
  • Index by author
Email

Thank you for your interest in spreading the word on European Respiratory Society .

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Osteopontin and soluble mesothelin-related peptide levels in malignant and benign diseases due to environmental asbestos exposure and healthy people with environmental asbestos exposure
(Your Name) has sent you a message from European Respiratory Society
(Your Name) thought you would like to see the European Respiratory Society web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Osteopontin and soluble mesothelin-related peptide levels in malignant and benign diseases due to environmental asbestos exposure and healthy people with environmental asbestos exposure
Mehmet Bayram, Isa Döngel, Ali Akbas, Nur Dilek Bakan, Ismail Benli
European Respiratory Journal Sep 2011, 38 (Suppl 55) p3317;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Osteopontin and soluble mesothelin-related peptide levels in malignant and benign diseases due to environmental asbestos exposure and healthy people with environmental asbestos exposure
Mehmet Bayram, Isa Döngel, Ali Akbas, Nur Dilek Bakan, Ismail Benli
European Respiratory Journal Sep 2011, 38 (Suppl 55) p3317;
del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo

Jump To

  • Article
  • Info & Metrics
  • Tweet Widget
  • Facebook Like
  • Google Plus One

More in this TOC Section

  • Chronic exposure to microcystin-LR: Pulmonary and upper respiratory tract impairment
  • LSC 2011 Abstract: Combined nasal exposure to sodium hypochlorite and ovalbumin induces airway hyperreactivity in mice through activation of the TRPA1 channel and mast cells
  • Adipokine adipsin is associated with the degree of parenchymal fibrosis in asbestos-exposed patients
Show more 368. Environmental exposure and disease mechanisms

Related Articles

Navigate

  • Home
  • Current issue
  • Archive

About the ERJ

  • Journal information
  • Editorial board
  • Reviewers
  • Press
  • Permissions and reprints
  • Advertising

The European Respiratory Society

  • Society home
  • myERS
  • Privacy policy
  • Accessibility

ERS publications

  • European Respiratory Journal
  • ERJ Open Research
  • European Respiratory Review
  • Breathe
  • ERS books online
  • ERS Bookshop

Help

  • Feedback

For authors

  • Instructions for authors
  • Publication ethics and malpractice
  • Submit a manuscript

For readers

  • Alerts
  • Subjects
  • Podcasts
  • RSS

Subscriptions

  • Accessing the ERS publications

Contact us

European Respiratory Society
442 Glossop Road
Sheffield S10 2PX
United Kingdom
Tel: +44 114 2672860
Email: journals@ersnet.org

ISSN

Print ISSN:  0903-1936
Online ISSN: 1399-3003

Copyright © 2022 by the European Respiratory Society