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QuantiFERON testing in British army recruits

Rachel Mackley, David Spence
European Respiratory Journal 2011 38: p308; DOI:
Rachel Mackley
Respiratory Medicine, Friarage Hospital, Northallerton, North Yorkshire, United Kingdom
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David Spence
Respiratory Medicine, Friarage Hospital, Northallerton, North Yorkshire, United Kingdom
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Abstract

Our hospital has links with an Army base and investigates recruits for Tuberculosis (TB). Many come from high prevalence areas. Recruits are screened with a Mantoux test. Those with a Mantoux reaction ≥15mm and no previous BCG vaccination are referred for QuantiFERON Gold testing. If positive they are treated for latent TB.

We reviewed referrals over a 2 year period (April 2008 - April 2010) to assess compliance with Army policy and investigate whether referral based on Mantoux reaction alone is warranted.

Demographic data were gathered from Army records. The relationship between a positive QuantiFERON test and a Mantoux reaction of ≥15mm was assessed using a Chi-squared test.

153 cases were identified, 28 were excluded due to insufficient data, leaving a sample of 125. All cases were male. Median age was 21.5 years (range 17-33). For analysis recruits were divided into 4 areas (see table 1).

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QuantiFERON and Mantoux results by Nationality

89 recruits (79%) had a positive QuantiFERON test. There was no significant relationship between QuantiFERON positivity and Mantoux size ≥ 15mm (p=0.0923).

Large numbers of recruits are referred based on their Mantoux results, including many with reactions of 6-14 mm. As there was no significant relationship between the rate of QuantiFERON positivity and Mantoux reaction size ≥ 15mm, referral decisions should not be made on this basis alone.

Further research is warranted to assess the current referral guidelines.

  • © 2011 ERS
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QuantiFERON testing in British army recruits
Rachel Mackley, David Spence
European Respiratory Journal Sep 2011, 38 (Suppl 55) p308;

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QuantiFERON testing in British army recruits
Rachel Mackley, David Spence
European Respiratory Journal Sep 2011, 38 (Suppl 55) p308;
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