Abstract
Introduction: Adenocarcinoma (ADC) was individualized within primary lung cancers from part their epidemiological, clinical and evolutionary particularities.
Objective: To describe diagnosis, managment and outcome of primary lung adenocarcinoma.
Methods: Retrospective study including 79 patients in whom diagnosis of primary lung ADC was made in our department between January 2002 and December 2010.
Results: All patients were males with mean age of 60 years. 94,9% of them were smokers. Functional signs were dominated by chest pain (41 patients) and sputum (36 patients). The chest radiograph showed proximal opacity in 47 patients. The histological diagnosis was allowed by bronchial biopsy in 44% of cases, trans-thoracic biopsy in 19% of cases, surgical biopsy in 25% of cases, pleural biopsy in 4% of cases and biopsy of remote metastasis in 8% of cases. Tumoral cells expressed CK7 in 32% of cases, TTF1 in 9% of cases, CK20 in 1,2% of the cases, EMA in 2,5% of the cases, CK5/6 in 2,5% of cases, Napsine in 4% of the cases, Kl1 in 4% of cases and PanCK in 1,2% of cases. 60% of the patients had cancer at stage IV. Surgery was performed in 20 patients (lobectomy in 19 patients and pneumonectomy in 1 patient). The chemotherapy was administrated in 49% of the patients. Curative radiotherapy was performed in 4 patients and palliative in 19 patients. Symptomatic treatment was decided in 26 patients. Recurrence after surgical treatment was noted in 50% of cases after a mean delay of 229,37 days. Mean survival of all patients was of 355,92 days.
Concusion: Diagnosis of pulmonary ADC is based on histological study. Most of our patients have metastatic disease when diagnosed explaining poorer prognosis.
- © 2011 ERS