Abstract
Relatively better cure rates are noted with use of daily TB chemotherapy regimens compared to intermittent regimens for TB lymphadenitis in our clinical experience. We therefore did a randomized comparative prospective study of daily vs. intermittent chemotherapy for cases with TB lymphadenitis. A total of 170 cases were randomly put on daily or intermittent regimen. Any cases of proven or suspected drug resistance were excluded. The regimens were selected as per the standard DOTS categories. 81 on daily and 73 on intermittent regimens completed their treatment and were available for analysis. 73/81 (90.12%) on daily regimen and 52/73 (71.23%) on intermittent regimens were cured. 17/81 (20.98%) and 23/73 (31.5%) respectively needed extension of treatment. 26/81 (32.09%) and 18/73 (24.65%) had adverse effects of chemotherapy on daily vs. intermittent treatment respectively. Daily TB chemotherapy seems to be superior to intermittent chemotherapy in terms of treatment outcome at the cost of slightly more adverse effects, in our study of TB lymphadenitis.
- © 2011 ERS
