Abstract
Purpose: There is a strong correlation between right ventricular ejection fraction (RVEF) and tricuspid annular plane systolic fraction (TAPSE) determined by echocardiography in subjects with pulmonary hypertension (PH). However, it is unknown whether there a correlation between RVEF and TAPSE determined by 320-slice CT. We tested whether TAPSE measured by enhance ECG-gated volume 320-slice CT correlates with RVEF and correlates with pulmonary arterial pressure (PAP) and pulmonary vascular resistance (PVR) obtained by right heart catheterization (RHC) in chronic thromboembolic pulmonary hypertension (CTEPH) subjects.
Materials and methods: 33 subjects (11 male, 61±10 yrs) with CTEPH underwent enhanced retrospective ECG-gated volume 320-slice CT (Aquilion ONE, Toshiba) and RHC. CT images were reconstructed every 5% from 0-95% of the R-R interval and a series of apical 4-chanber images. TAPSE was measured from systolic displacement of the RV freewall and tricuspid annular plane junction. RV end-systolic and end-diastolic true volumes were measured from 3-dimensional reconstruction and used to calculate RVEF.
Results: TAPSE and RVEF were 14.5±3.5mm and 47.0±14.3%, respectively. In RHC, mean PAP (mPAP) and PVR were 41±12 mmHg and 683±364 dyne sec cm-5, respectively. The correlation coefficient of TAPSE with RVEF was 0.78 (P<0.001). The correlation coefficients of TAPSE with mPAP and PVR were -0.63 (P<0.001) and -0.64 (P<0.001), respectively.
Conclusions: TAPSE by ECG-gated 320-slice CT correlated strongly with RVEF and significantly with mPAP and PVR acquired by RHC in subjects with CTEPH.
- © 2011 ERS
