Abstract
Obtructive Sleep Apnea Syndrome (OSAS) is an independent risk factor for the development of cardiovascular event and hypertension. Mean Platelet Volume (MPV); an indicator of platelet activation and aggregation which are closely related with cardiovascular diseases (CVD). We aimed to show the relationship between OSAS and MPV with CVD. The medical records of 205 subjects who were admitted for the sleep study were evaluated. OSAS was diagnosed by polysomnography if Apnea-Hypopnea Index (AHI) >5. MPV calculated from blood samples. According to AHI, individuals in whom AHI< 5 were recruited as group 1 (control group), those in whom AHI=5-15 group 2 (mild OSAS group), those in whom AHI=15-30 group 3 (moderate OSAS group), those in whom AHI >30 group 4 (severe OSAS group). Of the subjects 137 (67%) were male, 68 (33%) were female and the mean age was 53.0±14.1years. There were 35 (17%), 20 (10.2%), 40 (20.4%) and 108 (52.6%) in group 1, 2, 3 and 4 respectively. There were significant differences in terms of coronary artery disease and hypertension between all groups (p <0.05) Except group 1 and 2, other groups showed a significant increase in MPV was detected while the severity of OSAS increased ((group 1= 9.3±0.7, group 2= 9.4±0.8, group 3= 9.5±1.1, group 4= 10.2±1.2; p for trend 0.03). We have shown that MPV is significantly increased in patients with OSAS which is an independent risk factor CVD. MPV may use as a marker to predict CVD in OSAS.
- © 2011 ERS
