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Effect of CPAP treatment on endothelial function, inflammatory markers, blood pressure and glucose control in patients with OSAS with emphasis on gender differences

Athanasios Panoutsopoulos, Anastasios Kallianos, Apostolis Pappas, Lemonia Velentza, Christos Mermigkis, Kostantinos Kostopoulos, Vasileios Kouranos, Aggeliki Rapti, Eleni Koufogiorga, Aleksandra Mitrakou, Charalampos Kostopoulos, Nikolaos Zakopoulos, Ioannis Nikolopoulos
European Respiratory Journal 2011 38: p2227; DOI:
Athanasios Panoutsopoulos
1Clinic of Therapeutics, Aleksandra General Hospital University of Athens, Athens, Greece
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Anastasios Kallianos
22nd Pulmonary Clinic, General Hospital of Chest Diseases “Sotiria”, Athens, Greece
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Apostolis Pappas
1Clinic of Therapeutics, Aleksandra General Hospital University of Athens, Athens, Greece
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Lemonia Velentza
1Clinic of Therapeutics, Aleksandra General Hospital University of Athens, Athens, Greece
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Christos Mermigkis
3Pulmonary Clinic, 401 Army General Hospital, Athens, Greece
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Kostantinos Kostopoulos
1Clinic of Therapeutics, Aleksandra General Hospital University of Athens, Athens, Greece
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Vasileios Kouranos
48th Pulmonary Clinic, General Hospital of Athens “Sotiria”, Athens, Greece
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Aggeliki Rapti
22nd Pulmonary Clinic, General Hospital of Chest Diseases “Sotiria”, Athens, Greece
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Eleni Koufogiorga
1Clinic of Therapeutics, Aleksandra General Hospital University of Athens, Athens, Greece
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Aleksandra Mitrakou
1Clinic of Therapeutics, Aleksandra General Hospital University of Athens, Athens, Greece
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Charalampos Kostopoulos
1Clinic of Therapeutics, Aleksandra General Hospital University of Athens, Athens, Greece
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Nikolaos Zakopoulos
1Clinic of Therapeutics, Aleksandra General Hospital University of Athens, Athens, Greece
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Ioannis Nikolopoulos
5Clinic of Respiratory Failure, General Hospital of Chest Diseases “Sotiria”, Athens, Greece
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Abstract

Introduction: Research evidence suggests the presence of endothelial dysfunction and systemic inflammation in patients with obstructive sleep apnea syndrome (OSAS). The effects of CPAP on the aforementioned pathophysiologic pathways, as well as on the systemic disease that result or coexist with the OSAS remain elusive.

Aim: To assess the effect of CPAP therapy on endothelial-dependent dilation, plasma levels of inflammatory markers, blood pressure and glucose control in male and female patients with OSAS.

Methods: Our study group consisted of 40 patients with no prior history of cardiovascular disease, with an Apnea-Hypopnea Index (AHI) >15 who were assigned to receive CPAP treatment. Measurement of Flow Mediated Dilation (FMD), 24-hour ambulatory blood pressure (BP) and blood analysis were performed at baseline and 3 months after CPAP therapy.

Results: Baseline FMD values were negatively correlated the AHI (r=-0.55, p=0.001). After 3 months of CPAP there was a significant increase in the FMD values and a significant reduction in the patients' 24hr systolic BP, diastolic BP and Pulse Pressure (PP), daytime systolic and diastolic BP, nighttime systolic BP and PP, the C-reactive protein (CRP) and HbA1c levels. When divided by gender, only male patients produced similar statistically significant results.

Conclusion: Our results suggest that CPAP therapy improves the endothelial function, the blood pressure and glucose control in male patients with OSAS. Further research is warranted in order to further elucidate the impact of CPAP on the cardiovascular risk of male and female patients with OSAS.

  • © 2011 ERS
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Effect of CPAP treatment on endothelial function, inflammatory markers, blood pressure and glucose control in patients with OSAS with emphasis on gender differences
Athanasios Panoutsopoulos, Anastasios Kallianos, Apostolis Pappas, Lemonia Velentza, Christos Mermigkis, Kostantinos Kostopoulos, Vasileios Kouranos, Aggeliki Rapti, Eleni Koufogiorga, Aleksandra Mitrakou, Charalampos Kostopoulos, Nikolaos Zakopoulos, Ioannis Nikolopoulos
European Respiratory Journal Sep 2011, 38 (Suppl 55) p2227;

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Effect of CPAP treatment on endothelial function, inflammatory markers, blood pressure and glucose control in patients with OSAS with emphasis on gender differences
Athanasios Panoutsopoulos, Anastasios Kallianos, Apostolis Pappas, Lemonia Velentza, Christos Mermigkis, Kostantinos Kostopoulos, Vasileios Kouranos, Aggeliki Rapti, Eleni Koufogiorga, Aleksandra Mitrakou, Charalampos Kostopoulos, Nikolaos Zakopoulos, Ioannis Nikolopoulos
European Respiratory Journal Sep 2011, 38 (Suppl 55) p2227;
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More in this TOC Section

  • Severity of sleep-disordered breathing is an independent predictor of metabolic dysfunction in a population with obstructive sleep apnoea
  • Cognition, quality of life and adherence to CPAP after 18-months treatment in obstructive sleep apnea patients
  • Importance of controlled blood pressure values in a population with obstructive sleep apnea syndrome (OSA) and arterial hypertension (HT)
Show more 258. Cardiometabolic and neurocognitive changes in obstructive sleep apnoea

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