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Functional state of endothelium in bronchial asthma children

Natalya Orlova, Esfir Atkina, Larisa Guryeva, Lubov Babenkova, Gulnara Sakaeva, Alfia Biktasheva, Svetlana Levasheva
European Respiratory Journal 2011 38: p1144; DOI:
Natalya Orlova
Cathedra of Children Diseases, Bashkirian Medical University, Ufa, Bashkortostan, Russian Federation
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Esfir Atkina
Cathedra of Children Diseases, Bashkirian Medical University, Ufa, Bashkortostan, Russian Federation
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Larisa Guryeva
Cathedra of Children Diseases, Bashkirian Medical University, Ufa, Bashkortostan, Russian Federation
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Lubov Babenkova
Cathedra of Children Diseases, Bashkirian Medical University, Ufa, Bashkortostan, Russian Federation
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Gulnara Sakaeva
Cathedra of Children Diseases, Bashkirian Medical University, Ufa, Bashkortostan, Russian Federation
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Alfia Biktasheva
Cathedra of Children Diseases, Bashkirian Medical University, Ufa, Bashkortostan, Russian Federation
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Svetlana Levasheva
Cathedra of Children Diseases, Bashkirian Medical University, Ufa, Bashkortostan, Russian Federation
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Abstract

To examine the association between the functional state of endothelium and bronchial asthma the oxide nitrogen (NO) condition in blood samples was evaluated in 118 bronchial asthma children with a wide range of desease severity with the use of Yemchenko L.N. method (1994) by determination of terminal stabile metabolites, and endothelin-1 (ET-1) concentration with enzyme immunoassays analysis, and also with the use of J. Hladovec method (1978) of circulation endothelial cells (CEC) level establishing. The credible increase of ET-1 (0,525±0,06 fmol/ml), NO (66,59±4,45 mkM/ml), CEC (7,28±0,63 cells/100 mkl) levels in bronchial asthma children compared with control (0,22±0,01 fmol/ml, 29,86±0,77 mkM/ml, 3,03±0,22 accordingly, p<0,01). The levels of endothelial markers credibly decreased on the background of anti-inflammatory therapy by inhalative glucocorticosteroids (NO 82,69±14,38 mkM/ml and 42,12±9,66 mkM/ml, p=0,001; ET-1 0,64±0,15 fmol/ml and 0,35±0,06 fmol/ml, p=0,001; CEC 7,3±1,67 and 5,0±0,32 cells/100 mkl p=0,0017). All the trial results may be used as an additional standard definition of bronchial asthma severity and therapeutic efficiency in bronchial asthma children.

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Functional state of endothelium in bronchial asthma children
Natalya Orlova, Esfir Atkina, Larisa Guryeva, Lubov Babenkova, Gulnara Sakaeva, Alfia Biktasheva, Svetlana Levasheva
European Respiratory Journal Sep 2011, 38 (Suppl 55) p1144;

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Functional state of endothelium in bronchial asthma children
Natalya Orlova, Esfir Atkina, Larisa Guryeva, Lubov Babenkova, Gulnara Sakaeva, Alfia Biktasheva, Svetlana Levasheva
European Respiratory Journal Sep 2011, 38 (Suppl 55) p1144;
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