Abstract
There are many polymorphisms of genes involved in metabolism of compounds contained in tobacco smoke (MAOA, MAOB, DAT1 and DRD2). Dopamine (DA) is critical for reward and its predictive signals, genetically driven variation in DA transmission may account for the observed differences.
The aim of study was to examine interactions between DAT1 and MAOA polymorphisms and nicotine dependence, number of cigarettes and successful quit smoking in healthy smokers, patients with COPD and asthma.
Methods: 99 smokers-males (36-78 years) were genotyped for polymorphisms of DAT1, MAOA. CO breath testing has been made for cigarette consumption. Information about current tobacco consumption was obtained using self-report measures and structured interviews.
Results: Age at initiation of smoking was assessed at age 12 and 22 years. Results suggest that age at onset of intensive consumption and nicotine dependence (ND) moderated the association of the DAT1 gene. Individuals with DAT1 40 bp (6R, 7R, 8R, 9R) and DAT1 30bp (5R) had lower nicotine dependence and they quit smoking more successful than smokers with DAT1 40 bp (10R, 11R; p=0.038) and DAT1 30bp (6R, 7R; p=0.029). ND patients with COPD =5.24+0.36 (from 4 to 10), asthma = 3.15+0.44 (from 3 to 8). Patients with COPD more often had DAT1 40 bp (10R, 11R) than patients with asthma (p=0.039).
Have been revealed association between the MAOA polymorphism and smoking (r=0.48). Smokers with COPD and smokers with several nicotine withdrawal more often had 3R 4R MAOA.
Conclusion: These results support the hypothesis that the DAT1 and MAOA polymorphisms are associated with smoking cessation and can influence on smoking cessation in patients with COPD.
- © 2011 ERS
