Abstract
The aim of this study was to investigate clinical, nicotine dependence status in smoking tuberculosis (TB) and COPD pts, efficacy of treatment of nicotine dependence by nicotinic acetylcholine receptor agonist (cytizine), mexidol, behavioural intervention in TB and COPD pts.
Methods: 91 smoking TB and COPD pts (74m, 17w, age 41±1) were examined before and after 3 months of treatment. 50 Pts have been treated with 4-5 antituberculosis drugs, basic course of COPD (β2-agonist, anticholinergic, corticoids, O2), cytizine (1,5-6mg/day-25days), mexidol (100mg/day-25days), behavioural intervention. 41 Pts have received 4-5 antituberculosis drugs and basic course of COPD only (Gr2). Examination of clinical status, blood gases, pulmonary function tests, quiz pts about their smoking status had been performed in all pts.
Results: In TB and COPD pts was found low nicotine dependence, low motivation to quit. After 3 months of treatment in TB and COPD pts clinical status was improved. Smoking cessation was achieved in 16% pts of Gr1, decrease of nicotine consumption-in 60% pts of Gr1. In 76% pts of Gr1, in 71% pts of Gr2 was found improvement of chest X-ray. Sputum conversion was found in 80% pts of Gr1, in 73% pts of Gr2. In Gr1 was found increase of forced expiratory volume in 1 second for predicted on 14%, p<0,05, peak expiratory flow for predicted-on 13%, p<0,05, decrease of PCO2, on 14%, p<0,01, HCO3- on 8%, p<0,05. In Gr2 significant changes were not found.
Conclusion: In TB and COPD pts adding cytizine, mexidol, behavioural intervention to antituberculosis and basic course of COPD leads to decrease of level of nicotine consumption, improvement of clinical, blood gases exchange status, pulmonary function.
- © 2011 ERS