Abstract
Aim: To identify several biochemical marker levels in mesothelioma (MM), in subjects with pleural plaques (PP) due to environmental asbestos exposure (EAE) and in healthy subjects with EAE.
Method: 277 patients with PP from villages close to ophiolitic units (OU) (serpentin asbest containing), 121 healthy subjects from villages close to OU, 118 healthy subjects without EAE and 24 MM patients were included to the study.
Results: CA125, CA15-3, Folate, Vit B12,ferritin levels of MM patients were higher, fT3 levels of MM were lower.
Table 1. Distribution of sex, age and biochemical findings according to the groups
AUC of the CA125 and CA15-3 in identifying MM were 0.78 and 0.67 in ROC curve respectively.
Table 2. Several cut off values of markers differentiating mesothelioma from benign diseases
Other tumor markers were irrevelant.
Conclusion: CA125 and CA15-3 may have role on diagnosis of MM. Ferritin, folate, VitB12 levels were increased in MM patients where as fT3 levels were decreased.
- © 2011 ERS
