Skip to main content

Main menu

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • ERS Guidelines
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • Peer reviewer login
    • WoS Reviewer Recognition Service
  • Alerts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • ERS Guidelines
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • Peer reviewer login
    • WoS Reviewer Recognition Service
  • Alerts
  • Subscriptions

Ability of IGRAs for diagnosis of tuberculosis infection in adolescents, and role of non-tuberculous mycobacteria in the positivity of tuberculine skin test

Irene Mialdea, Irene Latorre, Empar Giner, Nuria Díez, Carme Salazar, Antonio Salazar, Jose Domínguez, Amparo Escribano
European Respiratory Journal 2011 38: 3396; DOI:
Irene Mialdea
1Unidad de Neumología Infantil, Hospital Clínico Universitario de Valencia, Universidad de Valencia, Valencia, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Irene Latorre
2Servei de Microbiologia, Hospital Universitari Germans Trias i Pujol, Fundaciό Institut d'Investigaciό en Ciències de la Salut Germans Trias i Pujol, Badalona, Barcelona, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Empar Giner
3Secciόn de Epidemiología, Centro de Salud Pública de Valencia, Valencia, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nuria Díez
1Unidad de Neumología Infantil, Hospital Clínico Universitario de Valencia, Universidad de Valencia, Valencia, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Carme Salazar
3Secciόn de Epidemiología, Centro de Salud Pública de Valencia, Valencia, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Antonio Salazar
3Secciόn de Epidemiología, Centro de Salud Pública de Valencia, Valencia, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jose Domínguez
2Servei de Microbiologia, Hospital Universitari Germans Trias i Pujol, Fundaciό Institut d'Investigaciό en Ciències de la Salut Germans Trias i Pujol, Badalona, Barcelona, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Amparo Escribano
1Unidad de Neumología Infantil, Hospital Clínico Universitario de Valencia, Universidad de Valencia, Valencia, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
Loading

Abstract

Introduction: A big drawback of tuberculin skin test (TST) is the cross-reaction with bacillus Calmette-Guérin (BCG) vaccine or with non-tuberculous mycobacteria (NTM). In this way, interferon-gamma release assays (IGRAs) are more specific but few data are available for children.

Aims and objectives: To assess the ability of IGRAs to detect Mycobacterium tuberculosis infection in healthy adolescents, and to know the influence of previous NTM sensitisation in discordant results as positive TST with negative IGRA.

Methods: TST was performed on 2,346 students aged 12-16 from Valencia city during the 2009-10 academic year. Those with TST ≥5 mm, underwent a checkup, a chest x-ray and QuantiFERON-TB GOLD In-Tube (QFT) test. Those with negative QFT, were tested by T-SPOT.TB (TSPOT) and T cells were stimulated with Mycobacterium avium sensitin (MAS).

Results: TST was ≥5 mm in 171 students (4.3%), and QFT was tested in 159. QFT was positive in 33 (21%) and it enabled to diagnose 10 individuals BCG-immunized with latent infection. QFT was negative in the 4 students with radiographic findings of previous tuberculosis (TB), and also in 14 from the 17 diagnosed with active TB. From those with negative QFT (126), TSPOT was tested in 95; it was positive in 5 (2 had been classed as vaccine reactions). Stimulation with MAS was positive in 15 (5 were not vaccinated and TSPOT was negative in all of them).

Conclusions: IGRAs help to detect infection in BCG-immunized, and to rule it out in doubtful cases, avoiding unnecessary treatments. Previous NTM sensitisation may explain some positive TSTs in non-vaccinated.

This work is supported by EVES and SENP grants

  • © 2011 ERS
Previous
Back to top
Vol 38 Issue Suppl 55 Table of Contents
  • Table of Contents
  • Index by author
Email

Thank you for your interest in spreading the word on European Respiratory Society .

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Ability of IGRAs for diagnosis of tuberculosis infection in adolescents, and role of non-tuberculous mycobacteria in the positivity of tuberculine skin test
(Your Name) has sent you a message from European Respiratory Society
(Your Name) thought you would like to see the European Respiratory Society web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Ability of IGRAs for diagnosis of tuberculosis infection in adolescents, and role of non-tuberculous mycobacteria in the positivity of tuberculine skin test
Irene Mialdea, Irene Latorre, Empar Giner, Nuria Díez, Carme Salazar, Antonio Salazar, Jose Domínguez, Amparo Escribano
European Respiratory Journal Sep 2011, 38 (Suppl 55) 3396;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Ability of IGRAs for diagnosis of tuberculosis infection in adolescents, and role of non-tuberculous mycobacteria in the positivity of tuberculine skin test
Irene Mialdea, Irene Latorre, Empar Giner, Nuria Díez, Carme Salazar, Antonio Salazar, Jose Domínguez, Amparo Escribano
European Respiratory Journal Sep 2011, 38 (Suppl 55) 3396;
del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo

Jump To

  • Article
  • Info & Metrics
  • Tweet Widget
  • Facebook Like
  • Google Plus One

More in this TOC Section

  • Transitional change of the relationship between clinical efficacy of treatment for pulmonary MAC disease and drug-sensitivity test for MAC isolated
  • High burden of rapidly growing non-tuberculosis mycobacteria in patients with respiratory disease undergoing elective bronchoscopy
Show more 378. Non-tuberculous mycobacteria pulmonary infections

Related Articles

Navigate

  • Home
  • Current issue
  • Archive

About the ERJ

  • Journal information
  • Editorial board
  • Press
  • Permissions and reprints
  • Advertising

The European Respiratory Society

  • Society home
  • myERS
  • Privacy policy
  • Accessibility

ERS publications

  • European Respiratory Journal
  • ERJ Open Research
  • European Respiratory Review
  • Breathe
  • ERS books online
  • ERS Bookshop

Help

  • Feedback

For authors

  • Instructions for authors
  • Publication ethics and malpractice
  • Submit a manuscript

For readers

  • Alerts
  • Subjects
  • Podcasts
  • RSS

Subscriptions

  • Accessing the ERS publications

Contact us

European Respiratory Society
442 Glossop Road
Sheffield S10 2PX
United Kingdom
Tel: +44 114 2672860
Email: journals@ersnet.org

ISSN

Print ISSN:  0903-1936
Online ISSN: 1399-3003

Copyright © 2023 by the European Respiratory Society