Abstract
Objectives: To determine the prevalence of anaemia in stable-phase COPD patients. To ascertain the differences in serum values of some biomarkers between COPD patients with and without anaemia.
Population and methods: COPD stable outpatients were included. These patients were followed up in the respiratory clinic and none of them could meet any of de following exclusion criteria: moderate-severe exacerbations in the last two months; asthma, thyroid disease, cancer in the last 5 years, liver disease, chronic heart or renal failure, any origin blood loss background, B12 vitamin and folic acid deficit. A set of tests were performed, including lung function test, blood samples for hemogram and biochemistry and serum values of ultrasensitive CRP, IL6, IL8 and TNFalfa. Bootstrap methodology has been used in order to test differences between with and without anaemia group.
Results: 130 patients were included, 116 (89,2%) were men, with an average age of 64,2 years (DS 8,4) and a FEV1% postbronchodilatador of 49,7% (DS 15,6). 8 patients showed anaemia (6,2%). A summary of the biomarkers results for each group is presented below.
Conclusions: The anaemia prevalence in COPD is 6,2% in our study. We have found significant differences in serum values of IL6 between COPD patients with and without anaemia. The CRP serum values in patients with COPD and anaemia were higher than the values in patients without anaemia.
This study has been partially financed by GlaxoSmithKline. SA. CRT114268.
- © 2011 ERS
