Figures
- Figure 1–
Survival in acute exacerbations (–––––) and sub-acute exacerbations (------) of idiopathic pulmonary fibrosis. Survival status at 1 yr was known for all patients; therefore survival curves represent actual data. Differences are expressed by log-rank test at 3 months, 6 months and 1 yr. #: p=0.05; ¶: p=0.18; +: p=0.35.
Tables
- Table 1– Characteristics of patients at baseline and at admission for exacerbation.
AE SAE p-value All Patients n 11 7 18 Baseline characteristics Males 9 (81.8) 7 (100) 0.49 16 (88.9) Caucasians 10 (90.9) 7 (100) 1 17 (94.4) Current or ex-smoker 5 (45.4) 4 (57.1) 1 9 (50) Room air Pa,O2 mmHg 75 (68–84) 74# 74.5 (68–84) FVC % pred 75 (70–78) 66 (57–78) 0.54 70 (62–78) DL,CO % pred 40.5 (36–46.5) 46 (38–49) 0.57 42 (38–47) 6MWD m 415 (350–420) 422.5 (380–457.5) 0.37 415 (350–425) Characteristics at time of exacerbation Age yrs 67 (65–72) 67 (58–73) 0.93 67 (65–72) BMI kg·m−2 28.8 (27.7–31.7) 26.4 (24.2–29) 0.22 27.9 (25.6–30.6) Time from onset of symptoms to admission days 7 (3–18) 47 (39–62) 0.003 18.5 (6–44) Proportion of new opacities on HRCT that were multifocal or diffuse 6/9 (66.7) 2/5 (40) 0.58 8/14 (57.1) Room air Pa,O2 mmHg 53.5 (47–59.5) 60 (54–66) 0.33 55 (51–68) Pa,O2/FI,O2 255 (224–283) 286 (257–314) 0.33 262 (243–324) FVC % pred 57 (51–61) 56 (50–65) 0.81 57 (50–64) DL,CO % pred 25 (19–34) 24 (22–37) 0.90 24 (22–34) Data are expressed as median (interquartile range) for continuous variables and n (%) or n/N (%) for categorical variables, unless otherwise stated. Data and groups were compared using Fisher's exact test and Mann–Whitney U-test. In all cases, two-sided tests were used; p-values <0.05 (shown in bold text) were deemed statistically significant. AE: acute exacerbation; SAE: sub-acute exacerbation; Pa,O2: arterial oxygen tension; FVC: forced vital capacity; % pred: % predicted; DL,CO: diffusion capacity of the lung for carbon monoxide; 6MWD: 6-min walking test distance; BMI: body mass index; HRCT: high-resolution computed tomography FI,O2: inspired oxygen fraction. #: n=1.
