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Time interval to conversion of interferon-γ release assay after exposure to tuberculosis

S.W. Lee, D.K. Oh, S.H. Lee, H.Y. Kang, C-T. Lee, J-J. Yim
European Respiratory Journal 2011 37: 1447-1452; DOI: 10.1183/09031936.00089510
S.W. Lee
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D.K. Oh
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S.H. Lee
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H.Y. Kang
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C-T. Lee
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J-J. Yim
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  • For correspondence: yimjj@snu.ac.kr
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    Figure 1–

    Schematic of the study protocol. CXR: chest radiography; LDCT: low-dose computed tomography; QFT-GIT: QuantiFERON® TB-Gold In-Tube; TST: tuberculin skin test; AFB: acid-fast bacillus; exam: examination; LTBI: latent tuberculosis infection; HR: isoniazid/rifampicin.

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    Figure 2–

    Interval between tuberculosis (TB) exposure and QuantiFERON® TB-Gold In-Tube (QFT-GIT; Cellestis, Carnegie, Australia) conversion among 27 contacts without active TB. Each numbered square represents one participant and is placed at the point at which the participant started to reside with the platoon. TST: tuberculin skin test.

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  • Table 1– Demographic and clinical characteristics of five patients with pulmonary tuberculosis
    Patient No.Age yrsSymptom duration# weeksTime from diagnosis¶ weeksAFB sputum smearMycobacterial sputum cultureRFLP patternRadiographic findings
    121124PositiveM. tuberculosisIndex caseCavitary consolidation in RUL
    22143NegativeM. tuberculosisSame as indexConsolidation in RML
    32153NegativeM. tuberculosisDifferent from indexBronchiolitis in LLL
    42140NegativeNegativeNABronchiolitis in RUL with pleural effusion
    522No symptoms0NegativeNegativeNABronchiolitis in RUL
    • Patients 3 and 5 were diagnosed based on abnormal low-dose computed tomography chest lesions. AFB: acid-fast bacillus; RFLP: restriction fragment length polymorphism; M. tuberculosis: Mycobacterium tuberculosis; RUL: right upper lobe; RML: right middle lobe; LLL: left lower lobe; NA: not applicable. #: duration of respiratory symptoms before isolation; ¶: to investigation

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Vol 37 Issue 6 Table of Contents
European Respiratory Journal: 37 (6)
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Time interval to conversion of interferon-γ release assay after exposure to tuberculosis
S.W. Lee, D.K. Oh, S.H. Lee, H.Y. Kang, C-T. Lee, J-J. Yim
European Respiratory Journal Jun 2011, 37 (6) 1447-1452; DOI: 10.1183/09031936.00089510

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Time interval to conversion of interferon-γ release assay after exposure to tuberculosis
S.W. Lee, D.K. Oh, S.H. Lee, H.Y. Kang, C-T. Lee, J-J. Yim
European Respiratory Journal Jun 2011, 37 (6) 1447-1452; DOI: 10.1183/09031936.00089510
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