Effect of allergic inflammation on ion transport in native tracheal epithelia. a, b) Original recordings of the effects of amiloride, cyclic adenosine 5′-monophosphate (cAMP)-dependent activation and uridine 5′-triphosphate (UTP)-dependent activation on transepithelial voltage (V_te) and transepithelial resistance (R_te) across freshly excised tracheal tissues from a) vehicle-treated and b) Aspergillus fumigatus extract (Af)-sensitised mice. R_te was determined from V_te deflections obtained by pulsed current injection. Representative results of n = 27–31 mice per group. c–g) Summary of c) basal equivalent short-circuit current (I_sc), d) amiloride-sensitive I_sc, e) amiloride-insensitive I_sc, f) cAMP-induced I_sc and g) UTP-induced I_sc in freshly excised tracheal tissues from Af-sensitised and vehicle-treated mice. Data are presented as mean±sem (n = 27–31 mice per group). Con.: control; IBMX: 3-isobutyl-1-methylxanthine; Fors.: forskolin. *: p<0.001 compared with vehicle-treated mice.