Figures
- Fig. 1—
European Early Lung Cancer project processing of blood samples. EBTB: European Bronchial Tissue Bank; WBC: white blood cells; EDTA: ethylenediamine tetraacetic acid.
- Fig. 2—
European Early Lung Cancer project processing of sputum. EBTB: European Bronchial Tissue Bank; DTT: dithiothreitol; HE: haematoxylin and eosin; PAP: papanicolaou test.
- Fig. 3—
European Early Lung Cancer project processing of lung tissue. EBTB: European Bronchial Tissue Bank; HE: haematoxylin and eosin.
- Fig. 4—
Flow-chart showing the management of the European Early Lung Cancer project. The thick grey lines indicate the linkage of the main tasks. SPLC: second primary lung cancer; CT: computed tomography; EBTB: European Bronchial Tissue Bank.
Tables
- Table 1—
Characteristics of lung cancer patients and controls recruited into European Early Lung Cancer project
Characteristic Patients# Control Subjects n 922 1524 Sex Male 674 (73.2) 1105 (72.6) Female 247 (26.8) 418 (27.4) Ethnicity White - European 838 (97.4) 1472 (96.8) White - Other 10 (1.2) 18 (1.2) Other 12 (1.4) 30 (2.0) Smoking status Never 53 (6.2) 424 (28.1) Former 466 (54.5) 645 (42.7) Current 336 (39.3) 440 (29.2) Occupational asbestos exposure No or unsure 667 (79.3) 1343 (89) Yes 174 (20.7) 166 (11) Education level Low 648 (80) 1033 (68.5) High¶ 162 (20) 474 (31.5) Continuous variables Age yrs 64.6±9.2 62.9±9.5 Tobacco consumption pack-yrs 41±25 22.2±24 Total smoking duration yrs 38.5±15.2 23.7±19.5 Histology Squamous 392 (42.8) Adenocarcinoma 412 (45) Large cell 45 (4.9) Mixed 11 (1.2) NSCLC unspecified 55 (6) Tumour stage at presentation N undetermined 37 (4.2) I 552 (62) II 221 (24.8) III 81 (9.1) IV 0 (0) Progressive disease+ 163 (22.1) Length of follow-up months+ 18 Data are presented as n (%) or mean±sd, unless otherwise stated. NSCLC: nonsmall cell lung cancer. #: includes patients with at least one sample available from tumour, biopsy, bronchial washing, sputum and blood; ¶: first degree, higher degree, professional qualification or university entrance; +: in November 2007.
- Table 2—
Biological specimens archived in the European Bronchial Tissue Bank
Specimen type n Blood Plasma 3524 White blood cells 2672 Sputum Frozen 386 Preserved 691 Bronchial lavage Frozen 463 Preserved 556 Primary lung cancer normal tissue Frozen 715 Preserved 724 Primary lung cancer tumour tissue Frozen 730 Preserved 806 Total 11267
