Skip to main content

Main menu

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • For authors
    • Instructions for authors
    • Submit a manuscript
    • Author FAQs
    • Open access
    • COVID-19 submission information
  • Alerts
  • Podcasts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • For authors
    • Instructions for authors
    • Submit a manuscript
    • Author FAQs
    • Open access
    • COVID-19 submission information
  • Alerts
  • Podcasts
  • Subscriptions

Pulmonary function and exercise capacity in survivors of congenital diaphragmatic hernia

M. G. Peetsold, H. A. Heij, A. F. Nagelkerke, H. IJsselstijn, D. Tibboel, P. H. Quanjer, R. J. B. J. Gemke
European Respiratory Journal 2009 34: 1140-1147; DOI: 10.1183/09031936.00181408
M. G. Peetsold
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
H. A. Heij
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
A. F. Nagelkerke
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
H. IJsselstijn
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
D. Tibboel
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
P. H. Quanjer
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
R. J. B. J. Gemke
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Abstract

Congenital diaphragmatic hernia (CDH) is associated with pulmonary hypoplasia and pulmonary hypertension. The objective of this study was to assess pulmonary function and exercise capacity and its early determinants in children and adolescents born with high-risk CDH (CDH-associated respiratory distress within the first 24 h) and to explore the relationship of these findings with CDH severity.

Of 159 patients born with high-risk CDH, 84 survived. Of the 69 eligible patients, 53 children (mean±sd age 11.9±3.5 yrs) underwent spirometry, lung volume measurements and maximal cardiopulmonary exercise testing (CPET). Results of the pulmonary function tests were compared with those from a healthy control group matched for sex, age and height.

CDH survivors had a significantly lower forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), FEV1/FVC, maximum mid-expiratory flow and peak expiratory flow when compared with healthy controls. The residual volume/total lung capacity ratio was significantly higher. Linear regression analysis showed that gastro-oesophageal reflux disease was an independent determinant of reduced FEV1 and FVC. CPET results were normal in those tested.

High-risk CDH survivors have mild to moderate pulmonary function abnormalities when compared with a healthy matched control group, which may be related to gastro-oesophageal reflux disease in early life. Exercise capacity and gas exchange parameters were normal in those tested, indicating that the majority of patients do not have physical impairment.

  • Congenital diaphragmatic hernia
  • exercise capacity
  • follow-up
  • pulmonary function testing

Footnotes

    • © ERS Journals Ltd
    View Full Text
    PreviousNext
    Back to top
    View this article with LENS
    Vol 34 Issue 5 Table of Contents
    European Respiratory Journal: 34 (5)
    • Table of Contents
    • Index by author
    Email

    Thank you for your interest in spreading the word on European Respiratory Society .

    NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

    Enter multiple addresses on separate lines or separate them with commas.
    Pulmonary function and exercise capacity in survivors of congenital diaphragmatic hernia
    (Your Name) has sent you a message from European Respiratory Society
    (Your Name) thought you would like to see the European Respiratory Society web site.
    CAPTCHA
    This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
    Print
    Alerts
    Sign In to Email Alerts with your Email Address
    Citation Tools
    Pulmonary function and exercise capacity in survivors of congenital diaphragmatic hernia
    M. G. Peetsold, H. A. Heij, A. F. Nagelkerke, H. IJsselstijn, D. Tibboel, P. H. Quanjer, R. J. B. J. Gemke
    European Respiratory Journal Nov 2009, 34 (5) 1140-1147; DOI: 10.1183/09031936.00181408

    Citation Manager Formats

    • BibTeX
    • Bookends
    • EasyBib
    • EndNote (tagged)
    • EndNote 8 (xml)
    • Medlars
    • Mendeley
    • Papers
    • RefWorks Tagged
    • Ref Manager
    • RIS
    • Zotero

    Share
    Pulmonary function and exercise capacity in survivors of congenital diaphragmatic hernia
    M. G. Peetsold, H. A. Heij, A. F. Nagelkerke, H. IJsselstijn, D. Tibboel, P. H. Quanjer, R. J. B. J. Gemke
    European Respiratory Journal Nov 2009, 34 (5) 1140-1147; DOI: 10.1183/09031936.00181408
    del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo
    Full Text (PDF)

    Jump To

    • Article
      • Abstract
      • MATERIAL AND METHODS
      • RESULTS
      • DISCUSSION
      • Statement of interest
      • Acknowledgments
      • References
    • Figures & Data
    • Info & Metrics
    • PDF
    • Tweet Widget
    • Facebook Like
    • Google Plus One

    More in this TOC Section

    • Chronological expression of Ciliated Bronchial Epithelium 1 during pulmonary development
    Show more Original Articles: Paediatric respiratory disease and lung development

    Related Articles

    Navigate

    • Home
    • Current issue
    • Archive

    About the ERJ

    • Journal information
    • Editorial board
    • Reviewers
    • CME
    • Press
    • Permissions and reprints
    • Advertising

    The European Respiratory Society

    • Society home
    • myERS
    • Privacy policy
    • Accessibility

    ERS publications

    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS books online
    • ERS Bookshop

    Help

    • Feedback

    For authors

    • Instructions for authors
    • Submit a manuscript
    • ERS author centre

    For readers

    • Alerts
    • Subjects
    • Podcasts
    • RSS

    Subscriptions

    • Accessing the ERS publications

    Contact us

    European Respiratory Society
    442 Glossop Road
    Sheffield S10 2PX
    United Kingdom
    Tel: +44 114 2672860
    Email: journals@ersnet.org

    ISSN

    Print ISSN:  0903-1936
    Online ISSN: 1399-3003

    Copyright © 2021 by the European Respiratory Society