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Exhaled biomarkers in lung cancer

I. Horváth, Z. Lázár, N. Gyulai, M. Kollai, G. Losonczy
European Respiratory Journal 2009 34: 261-275; DOI: 10.1183/09031936.00142508
I. Horváth
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Z. Lázár
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N. Gyulai
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M. Kollai
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G. Losonczy
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Abstract

Lung cancer is the leading cause of cancer death. Results of therapeutic interventions are particularly discouraging when the disease is discovered in an advanced stage. Early diagnosis is limited by the fact that the disease usually develops asymptomatically and available screening methods do not fulfil the requirements for reliable discrimination between patients with lung cancer and subjects not suffering from the disease. Breath sampling is completely noninvasive and provides a potentially useful approach to screening lung cancer. Exhaled biomarkers contain both volatile and nonvolatile molecules. The profile of volatile organic compounds is different in patients with lung cancer than in control subjects. In exhaled breath condensate, the proteomic profile of breath from cancer patients differs from that of healthy smokers. We reviewed the scientific evidence demonstrating that a unique chemical signature can be detected in the breath of patients with lung cancer and that the exhaled breath biomarker profile could aid clinical decision making.

  • Biomarker
  • electronic nose
  • exhaled breath
  • exhaled breath condensate
  • lung cancer
  • smell

SERIES “LUNG CANCER”

Edited by C. Brambilla

Number 7 in this Series

Footnotes

  • Previous articles in this series: No. 1: De Wever W, Stroobants S, Coden J, et al. Integrated PET/CT in the staging of nonsmall cell lung cancer: technical aspects and resection for lung cancer. Eur Respir J 2009; 33: 201–212. No. 2: Rami-Porta R, Tsuboi M. Sublobar resection for lung cancer. Eur Respir J 2009; 33: 426–435. No. 3: McWilliams A, Lam B, Sutedja T. Early proximal lung cancer diagnosis and treatment. Eur Respir J 2009; 33: 656–665. No. 4: Sculier J-P, Moro-Sibilot D. First- and second-line therapy for advanced nonsmall cell lung cancer. Eur Respir J 2009; 33: 916–930. No. 5: van Tilburg PMB, Stam H, Hoogsteden HC, et al. Pre-operative pulmonary evaluation of lung cancer patients: a review of the literature. Eur Respir J 2009; 33: 1206–1215. No. 6: Brambilla E, Gazdar A. Pathogenesis of lung cancer signalling pathways: roadmap for therapies. Eur Respir J 2009; 33: 1485–1497.

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European Respiratory Journal: 34 (1)
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Exhaled biomarkers in lung cancer
I. Horváth, Z. Lázár, N. Gyulai, M. Kollai, G. Losonczy
European Respiratory Journal Jul 2009, 34 (1) 261-275; DOI: 10.1183/09031936.00142508

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Exhaled biomarkers in lung cancer
I. Horváth, Z. Lázár, N. Gyulai, M. Kollai, G. Losonczy
European Respiratory Journal Jul 2009, 34 (1) 261-275; DOI: 10.1183/09031936.00142508
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  • Article
    • Abstract
    • BREATH TESTS TO DETECT LUNG CANCER
    • POTENTIAL PLACE OF BREATH FINGERPRINTS IN DETECTING LUNG CANCER
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