MDCT variables | Univariate analysis | Multivariate analysis# |
Estimated difference between males and females (95% CI) | p-value | Estimated difference between males and females (95% CI) | p-value |
MLD HU | -10.63 (-14.11– -7.16) | <0.0001 | -17.00 (-20.34– -13.65) | <0.0001 |
15th percentile point HU | -8.85 (-11.35– -6.35) | <0.0001 | -12.75 (-15.13– -10.36) | <0.0001 |
Whole-lung emphysema proportion % | 1.20 (0.66–1.73) | <0.0001 | 2.00 (1.49–2.51) | <0.0001 |
Whole-lung core emphysema proportion % | 1.33 (0.74–1.92) | <0.0001 | 2.10 (1.54–2.66) | <0.0001 |
Whole-lung peel emphysema proportion % | 1.03 (0.54–1.53) | <0.0001 | 1.89 (1.42–2.36) | <0.0001 |
Core/peel ratio | 0.12 (0.08–0.17) | <0.0001 | 0.10 (0.06–0.14) | <0.0001 |
Emphysema proportion by pulmonary lobe % | | | | |
Left lower | 1.15 (0.62–1.68) | <0.0001 | 1.91 (1.39–2.43) | <0.0001 |
Left upper | 1.53 (0.89–2.16) | <0.0001 | 2.48 (1.86–3.09) | <0.0001 |
Right lower | 0.84 (0.30–1.38) | 0.0023 | 1.52 (0.99–2.04) | <0.0001 |
Right middle | 2.19 (1.41–2.98) | <0.0001 | 3.10 (2.31–3.89) | <0.0001 |
Right upper | 0.84 (0.29–1.40) | 0.0028 | 1.58 (1.04–2.12) | <0.0001 |
Emphysema proportion by cluster classes % | | | | |
1 | 0.166 (0.092–0.240) | <0.0001 | -0.21 (-0.42–0.00) | 0.054 |
2 | 0.288 (0.204–0.373) | <0.0001 | 0.40 (0.31–0.48) | <0.0001 |
3 | 0.050 (0.033–0.067) | <0.0001 | 0.08 (0.06–0.09) | <0.0001 |
4 | 0.663 (0.235–1.092) | 0.0025 | 1.31 (0.89–1.73) | <0.0001 |