Figures
- Fig. 1—
Changes in clinical markers following 2 weeks of intravenous antibiotic therapy. FEV1: forced expiratory volume in one second, WCC: white cell count; ESR: erythrocyte sedimentation rate; CRP: C-reactive protein; SGRQ: St George’s Respiratory Questionnaire.
Tables
- Table 1—
Patient characteristics
Subjects n 32 Male 10 (31.3) Age yrs 62.8±9.8 Nonsmokers 23 (71.9) Ex-smokers 9 (28.1) Ex-smoker pack-yr history 34.5±17.2 COPD 3 (9.4) Asthma 18 (56.3) Inhaled corticosteroid therapy 28 (87.5) Nebulised bronchodilator therapy 7 (21.9) FEV1 L 1.57±0.58 FEV1 % predicted 66.5±27.3 FVC L 2.49±0.78 FVC % predicted 85.3±33.2 Infective exacerbations in preceding year 7.4±6.0 Number of lobes involved on HRCT 4.1±1.7 Cystic bronchiectasis 10 (31.2) Chronically colonised 29 (90.6) Data are expressed as n (%) or mean±sd, unless otherwise stated. COPD: chronic obstructive pulmonary disease; FEV1: forced expiratory volume in one second; FVC: forced vital capacity; HRCT: high-resolution computed tomography.
- Table 2—
Aetiology of bronchiectasis
Inactive allergic bronchopulmonary aspergillosis 11 (34.4) Burnt out sarcoidosis 1 (3.1) Post infective (pneumonia, tuberculosis, pertussis, measles) 10 (31.3) Ig deficiency (all IgG subclass 2) 4 (12.5) Ciliary dyskinesia 1 (3.1) Idiopathic 5 (15.6) Data are presented as n (%). Ig: immunoglobulin.
- Table 3—
Outcome measures from start to end of exacerbation
Variable Start of exacerbation End of exacerbation p-value 24-h sputum volume mL 30.4±21.9 8.5±8.4 <0.0001 FEV1 L 1.45±0.57 1.52±0.58 0.07 FVC L 2.35±0.78 2.5±0.86 0.01 FEV1/FVC 61.4±12.3 60.4±11.5 0.5 Exercise capacity m 217.0±168.0 271±184.0 <0.0001 WCC# x109·L−1 10.8±7.1 7.2±2.5 <0.0001 ESR mm·h−1 40.1±27.4 22.3±14.1 <0.0001 CRP mg·L−1 66.9±70.7 7.4±11.2 <0.0001 Data are presented as mean±sd, unless otherwise stated. FEV1: forced expiratory volume in one second; FVC: forced vital capacity; WCC: white cell count; ESR: erythrocyte sedimentation rate; CRP: C-reactive protein. #: normal range 4–11×109·L−1.
- Table 4—
Individual domain and total St George’s Respiratory Questionnaire scores from start to end of exacerbation
Domain Start of exacerbation End of exacerbation p-value Symptoms 76.4±12.9 51.7±23.1 <0.0001 Activity 65.5±26.4 57.4±26.5 0.01 Impact 47.9±18.4 37.2±19.2 <0.001 Total score 57.9±17.5 45.7±20.0 <0.0001 Data are presented as mean±sd, unless otherwise stated.
